Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis.
Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis.
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DOI：
10.1002/(sici)1097-4636(19990915)46:4
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发表时间：
1999-09
期刊：
影响因子：
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通讯作者：
M. Yağmurlu;F. Korkusuz;I. Gursel;P. Korkusuz;Ülken Örs;V. Hasırcı;V. Hasırcı
中科院分区：
文献类型：
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作者：
M. Yağmurlu;F. Korkusuz;I. Gursel;P. Korkusuz;Ülken Örs;V. Hasırcı;V. Hasırcı
在这项研究中，开发了一种新型抗生素载体系统，用于治疗植入相关的慢性骨髓炎。将舒巴坦-头孢哌酮引入聚羟基丁酸酯-羟基戊酸酯（22 mol% HV，w/w）棒中，聚羟基丁酸酯-羟基戊酸酯是微生物来源聚合物家族的一员，由于其压电特性，具有生物可降解性、生物相容性和骨传导性。将载有抗生素的载体植入兔子胫骨中由金黄色葡萄球菌接种引起的感染部位。其有效性通过宏观、放射学、细菌学和组织病理学进行评估。第 15 天感染消退，第 30 天观察到几乎完全缓解。然而，含有不含抗生素棒的对照侧病情恶化。这些发现促使我们得出结论，本研究中开发的新型可生物降解抗生素载体似乎是用于治疗严重骨感染的有希望的候选者。
In this study, a novel antibiotic carrier system for use in the treatment of implant-related and chronic osteomyelitis was developed. Sulbactam-cefoperazone was introduced to rods of polyhydroxybutyrate-co-hydroxyvalerate (22 mol % HV, w/w), a member of a family of microbial-origin polymer that is biodegradable, biocompatible, and osteoconductive due to its piezoelectric property. The antibiotic-loaded carrier was implanted into the infection site that was induced by Staphylococcus aureus inoculation into the rabbit tibia. The effectiveness of this was assessed macroscopically, radiographically, bacteriologically, and histopathologically. Findings of infection subsided on day 15 and almost complete remission was observed on day 30. The control side that contained antibiotic-free rods, however, worsened. These findings prompted us to conclude that the novel biodegradable antibiotic carrier developed in the present study seems to be a promising candidate for use in the treatment of severe bone infection.