The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets
The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets
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DOI：
10.1016/s0028-3908(01)00182-4
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发表时间：
2002-03-01
影响因子：
4.7
通讯作者：
Grélot, L
中科院分区：
文献类型：
--
作者：
Girod, V;Dapzol, J;Grélot, L
我们分析了四种环氧合酶(COX)抑制剂对顺铂诱导的仔猪呕吐的影响。95只动物接受顺铂(5.5 mg kg(-1))静脉注射。在顺铂前1小时，对照组(n=29)给予生理盐水，实验动物静注。或者IP。注射一种环氧合酶抑制剂。在顺铂给药后15和39h(或双氯芬酸组每隔6h)再注射COX抑制剂。静脉注射萘普生组(4.66+/-0.94h，n=9，30 mg kg(-1))和吲哚美辛组(6.19+/-1.13h，n=7，10 mg kg(-1))首次呕吐发作潜伏期(EE)较对照组(2.1+/-0.4h)延长。消炎痛显著降低了呕吐的急性期(40%)和延迟期(66%)的发生率。服用消炎痛(14.9+/-3.2EE，n=7)和美洛昔康(17.6+/-3.6EE，n=11，0.3 mg kg(-1))的仔猪在60h内的EE总数显著低于对照组(28.3+/-1.9EE，n=7)。4头仔猪静脉注射美洛昔康0.3 mg kg(-1)。在延迟期没有呕吐。两种COX抑制剂的止吐活性表明，前列腺素有助于顺铂引起的呕吐反射的激活。(C)2002爱思唯尔科学有限公司。保留所有权利。
We analysed the effects of four cyclooxygenases (COX) inhibitors on cisplatin-induced emesis in piglets. Ninety-five animals receiving cisplatin (5.5 mg kg(-1), i.v.) were observed for 60 h. One hour prior to cisplatin, controls (n=29) were dosed with a saline solution while experimental animals received an i.v. or i.p. injection of one of the COX inhibitors. Additional injections of COX inhibitor were given at 15 and 39 h after cisplatin administration (or every 6 h in one group receiving diclofenac). The latencies to the first emetic episode (EE) compared to controls (2.1+/-0.4 h) increased in groups receiving naproxen (4.66+/-0.94 h, n=9, 30 mg kg(-1)) and indomethacin (6.19+/-1.13 h, n=7, 10 mg kg(-1)) i.v. Indomethacin significantly decreased the incidence of both the acute (by 40%) and delayed (by 66%) phases of emesis. The total number of EE during the 60 h compared to controls (28.3+/-1.9 EE) was significantly reduced in piglets receiving indomethacin (14.9+/-3.2 EE, n=7) and meloxicam (17.6+/-3.6 EE, n=11, 0.3 mg kg(-1)). Four piglets receiving meloxicam (0.3 mg kg(-1), i.v.) did not vomit during the delayed phase. The anti-emetic activity of two COX inhibitors suggests that prostaglandins contribute to the activation of the emetic reflex in response to cisplatin. (C) 2002 Elsevier Science Ltd. All rights reserved.