VIRULENT-AVIRULENT CONVERSIONS OF RICKETTSIA RICKETTSII INVITRO
VIRULENT-AVIRULENT CONVERSIONS OF RICKETTSIA RICKETTSII INVITRO
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DOI：
10.1073/pnas.41.11.870
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发表时间：
1955-01-01
影响因子：
11.1
通讯作者：
PRICE, WH
中科院分区：
文献类型：
--
作者：
GILFORD, JH;PRICE, WH
本文报道了(A)用对氨基苯甲酸在体外将致病立克次体转化为无毒状态；(B)通过添加辅酶I或辅酶A使PABA无毒立克次体和节肢动物无毒立克次体在体外重新激活或转化为致病状态；(C)观察到豚鼠的致病状态与立克次体对切碎的豚鼠皮肤的吸附能力平行。
In this paper is reported (a) the in vitro conversion of virulent R. rickettsii to an avirulent state by para-aminobenzoic acid; (b) the in vitro reactivation or conversion of the PABA-avirulent and arthropod-avirulent rickettsiae to the virulent form by the addition of Coenzyme I or Coenzyme A; and (c) the observation that the state of virulence for guinea pigs parallels the adsorptivity of R. rickettsii to minced guinea pig tunica.