Experimental validation of an extended Jones matrix calculus model to study the 3D structural orientation of the collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography.
Experimental validation of an extended Jones matrix calculus model to study the 3D structural orientation of the collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography.
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DOI：
10.1364/boe.3.000378
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Matcher SJ
中科院分区：
文献类型：
--
作者：
Kasaragod DK;Lu Z;Jacobs J;Matcher SJ
我们报告的结果，以验证一个理论框架来分析的三维深度方向的结构组织的胶原纤维在关节软骨中使用偏振敏感光学相干断层扫描。采用时域偏振敏感光学相干层析成像系统从多角度测量获得的表观双折射数据与基于扩展琼斯矩阵演算的模拟数据进行了比较。实验数据已被证明同意与先前提出的基于扫描电子显微镜数据的软骨微观结构的层状模型。该工具可能在关节镜检查过程中无创地绘制软骨胶原结构取向信息方面具有潜在的应用。
We report results to verify a theoretical framework to analyze the 3D depth-wise structural organization of collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography. Apparent birefringence data obtained from multi-angle measurements using a time domain polarization-sensitive optical coherence tomography system has been compared with simulated data based on the extended Jones matrix calculus. Experimental data has been shown to agree with the lamellar model previously proposed for the cartilage microstructure based on scanning electron microscopy data. This tool could have potential application in mapping the collagen structural orientation information of cartilage non-invasively during arthroscopy.