Orientational and motional properties of copper (II) complexes of dibenzotetraaza [14]annulenes in lipid bilayers: an ESR study.
Orientational and motional properties of copper (II) complexes of dibenzotetraaza [14]annulenes in lipid bilayers: an ESR study.
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脂质双层中二苯并四氮杂[14]轮烯的铜 (II) 配合物的取向和运动特性：一项 ESR 研究。
DOI：
10.1016/0162-0134(91)80060-u
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发表时间：
1991
影响因子：
3.9
通讯作者：
Subczynski,WK
中科院分区：
文献类型：
--
作者：
Pezeshk,A;Pezeshk,V;Subczynski,WK
本文报道了二肉豆蔻酰磷脂酰胆碱（DMPC）和蛋黄磷脂酰胆碱（EYPC）中取代二苯并四氮杂[14]轮烯铜（Ⅱ）配合物CuL和CuLA的ESR研究。我们的数据表明，这两个复合物分区到膜和CuL的旋转运动比CuLA更快。这些配合物在DMPC囊泡的ESR谱分析表明，铜运动参数，这是一个衡量的分辨率的氮超精细结构的程度，突然改变的主要相变。在1摩尔%下，两种络合物均使流体/凝胶相变温度降低2°C，如通过Cu-运动参数所测量。在相同的温度范围内，在EYPC脂质体中观察到Cu运动参数的逐渐变化。ESR谱的CuL和CuLA在定向膜显示，这两个复合物是很好地定向与平面的复合物垂直的双层表面。
ESR studies of two copper(II) complexes of substituted dibenzotetraaza[14]annulenes, CuL and CuLA, in dimyristoylphosphatidylcholine (DMPC) and egg yolk phosphatidylcholine (EYPC) are reported. Our data show that both complexes partition into the membranes and that the rotational motion of CuL is faster than CuLA. Analysis of the ESR spectra of these complexes in DMPC vesicles indicate that the Cu-motion parameter, which is a measure of the degree of resolution of the nitrogen hyperfine structure, changes abruptly at the main phase transition. At 1 mole %, both complexes lowered the fluid/gel phase transition temperature by 2°C as measured by the Cu-motion parameter. A gradual change of the Cu-motion parameter is observed in EYPC liposomes over the same temperature range. ESR spectra of both CuL and CuLA in oriented membranes reveal that both complexes are well oriented with the plane of the complex perpendicular to the bilayer surface.