The scarless heart and the MRL mouse
The scarless heart and the MRL mouse
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DOI：
10.1098/rstb.2004.1468
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发表时间：
2004-05-29
期刊：
影响因子：
--
通讯作者：
Clark, L
中科院分区：
文献类型：
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作者：
Heber-Katz, E;Leferovich, J;Clark, L
在许多非哺乳动物物种中都可以看到以最坚固的形式再生组织和肢体的能力。偶然发现 MRL 小鼠在某些方面具有与经典蝾螈和蝾螈物种相媲美的强大再生能力，这提出了人类也可能具有先天再生能力的可能性。成年 MRL 小鼠能够以近乎完美的保真度再生软骨、皮肤、毛囊和心肌，并且不会留下疤痕。这可以从关闭贯穿耳孔的能力中看出，耳孔通常用于小鼠的终生识别，以及严重冷冻损伤后心肌的解剖和功能恢复。我们提供的组织学、生化和遗传数据表明，疤痕样组织的增强分解可能是 MRL 再生反应的潜在因素。讨论了关于再生 MRL 组织中细胞来源的研究。此类研究似乎支持细胞替代的多种机制。
The ability to regenerate tissues and limbs in its most robust form is seen in many non-mammalian species. The serendipitous discovery that the MRL mouse has a profound capacity for regeneration in some ways rivalling the classic newt and axolotl species raises the possibility that humans, too, may have an innate regenerative ability. The adult MRL mouse regrows cartilage, skin, hair follicles and myocardium with near perfect fidelity and without scarring. This is seen in the ability to close through-and-through ear holes, which are generally used for lifelong identification of mice, and the anatomic and functional recovery of myocardium after a severe cryo-injury. We present histological, biochemical and genetic data indicating that the enhanced breakdown of scar-like tissue may be an underlying factor in the MRL regenerative response. Studies as to the source of the cells in the regenerating MRL tissue are discussed. Such studies appear to support multiple mechanisms for cell replacement.