Nanomedicine: controlling nanoparticle clearance for translational success.
Nanomedicine: controlling nanoparticle clearance for translational success.
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DOI：
10.1016/j.tips.2022.05.001
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发表时间：
2022-05
影响因子：
13.8
通讯作者：
Geyunjian H Zhu;Alex B.C. Gray;H. Patra
中科院分区：
文献类型：
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作者：
Geyunjian H Zhu;Alex B.C. Gray;H. Patra
实现完全的纳米颗粒（NP）清除是设计安全和可翻译的纳米药物的关键考虑因素。肾脏可清除的纳米制剂必须包含有益的纳米级功能，同时表现出像小分子治疗剂那样的清除特征。该领域的最新发展使得具有可转化尺寸的新型肾可清除NP的生长成为可能，其利用替代清除机制来实现受控和有效的肾排泄，以改善潜在的临床转化。
Achieving complete nanoparticle (NP) clearance is a key consideration in the design of safe and translatable nanomedicines. Renal-clearable nano formulations must encompass the beneficial nanoscale functionalities whilst exhibiting clearance profiles like those of small-molecule therapeutics. Recent developments in the field have enabled the growth of novel renal-clearable NPs with transformable sizes that take advantage of alternative clearance mechanisms to achieve controlled and efficient renal excretion to improve potential clinical translation.