Social support, social strain and inflammation: Evidence from a national longitudinal study of U.S. adults
Social support, social strain and inflammation: Evidence from a national longitudinal study of U.S. adults
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DOI：
10.1016/j.socscimed.2014.02.013
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发表时间：
2014-04-01
影响因子：
5.4
通讯作者：
Harris, Kathleen Mullan
中科院分区：
文献类型：
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作者：
Yang, Yang Claire;Schorpp, Kristen;Harris, Kathleen Mullan
长期以来，社会关系一直被认为对健康和生存有着强大的影响，但目前尚不清楚这种关联是否随时间的推移而因功能和关系领域而有所不同，以及这些联系背后的生物生理机制是什么。这项研究通过检查十年跨度内持久关系质量与免疫功能主要指标的纵向关联来解决这些差距。具体来说，我们研究了在之前的时间点与家人，朋友和配偶的关系中感知的社会支持和社会压力如何与随后的炎症风险相关，如由五个标志物组成的整体炎症负担所评估的那样。（C-反应蛋白，白细胞介素-6，纤维蛋白原，E-选择素，和细胞内粘附分子-1）在美国中年发展的647名成年人的国家纵向研究中（1995-2009）。多变量回归分析的结果显示：（1）来自家庭、朋友和配偶的支持适度地保护了炎症的风险;（2）家庭、朋友和总的社会压力大大增加了炎症的风险;（3）社会压力的负相关性强于社会支持与炎症的正相关性。研究结果强调了丰富的概念化，措施和社会和生物压力过程的纵向分析的重要性，以阐明将社会关系与健康和疾病联系起来的复杂途径。(C)2014爱思唯尔有限公司版权所有。
Social relationships have long been held to have powerful effects on health and survival, but it remains unclear whether such associations differ by function and domain of relationships over time and what biophysiological mechanisms underlie these links. This study addressed these gaps by examining the longitudinal associations of persistent relationship quality across a ten year span with a major indicator of immune function. Specifically, we examined how perceived social support and social strain from relationships with family, friends, and spouse at a prior point in time are associated with subsequent risks of inflammation, as assessed by overall inflammation burden comprised of five markers (C-reactive protein, interleukin-6, fibrinogen, E-selectin, and intracellular adhesion molecule-1) in a national longitudinal study of 647 adults from the Midlife Development in the United States (1995-2009). Results from multivariate regression analysis show that (1) support from family, friends, and spouse modestly protected against risks of inflammation; (2) family, friend, and total social strain substantially increased risks of inflammation; and (3) the negative associations of social strain were stronger than the positive associations of social support with inflammation. The findings highlight the importance of enriched conceptualizations, measures, and longitudinal analyses of both social and biological stress processes to elucidate the complex pathways linking social relationships to health and illness. (C) 2014 Elsevier Ltd. All rights reserved.