Cellular responses to DNA damage
Cellular responses to DNA damage
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DOI：
10.1016/s0955-0674(98)80146-4
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发表时间：
1998-04-01
影响因子：
7.5
通讯作者：
Wang, JYJ
中科院分区：
文献类型：
--
作者：
Wang, JYJ
细胞接触 DNA 损伤诱导剂会引发广泛的细胞反应，包括基因表达的改变、细胞周期进程的延迟和 DNA 修复的刺激。在多细胞生物中，DNA 损伤也会激活程序性细胞死亡。最近，已经确定了将 DNA 损伤与基因表达和细胞周期检查点联系起来的几种信号传导途径。这些途径为未来 DNA 损伤反应的研究建立了框架。 (C) Current Biology Ltd ISSN 0955-0674。
The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNA repair. In multicellular organisms, DNA damage can also activate programmed cell death. Recently, several signaling pathways that link DNA damage to gene expression and to the cell-cycle checkpoints have been identified. These pathways establish a framework for future studies of DNA damage responses. (C) Current Biology Ltd ISSN 0955-0674.