A large proportion of mediastinal and perirenal visceral fat of Siberian adult people is formed by UCP1 immunoreactive multilocular and paucilocular adipocytes
A large proportion of mediastinal and perirenal visceral fat of Siberian adult people is formed by UCP1 immunoreactive multilocular and paucilocular adipocytes
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DOI：
10.1007/s13105-019-00721-4
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发表时间：
2020-05-01
影响因子：
3.4
通讯作者：
Cinti, Saverio
中科院分区：
文献类型：
--
作者：
Efremova, Agrafena;Senzacqua, Martina;Cinti, Saverio
脂肪过多堆积对健康造成的许多有害后果都是由于内脏脂肪造成的。内脏脂肪的褐变主要依赖于冷，并且已被提议作为未来治疗肥胖和相关疾病的可能工具。在本文中，我们研究了生活在西伯利亚（地球上最冷的地区之一）的成年人尸检时收集的纵隔和肾周内脏脂肪的成分。数据显示，纵隔和肾周脂肪的一致部分（高达约 40%）具有典型的棕色脂肪细胞形态，并且其中相关百分比（高达约 30%）也表达功能标记解偶联蛋白 1 (UCP1)。主要生活在户外的患者的棕色样脂肪细胞比例较高，UCP1 免疫反应细胞也较强烈。大量 UCP1 免疫反应性少眼细胞（脂肪细胞转分化的过渡阶段）的存在支持了成年人在生理条件下内脏脂肪可以转化为棕色脂肪组织的观点。酪氨酸羟化酶免疫反应性去甲肾上腺素能实质神经纤维与纵隔脂肪中的多房脂肪细胞数量呈正相关，肾周脂肪中也观察到类似的趋势。
Many deleterious consequences for health of excessive fat accumulation are due to visceral fat. Browning of visceral fat is mainly cold dependent and has been proposed as a possible tool for future therapies of obesity and related disorders. In this paper, we studied the composition of mediastinal and perirenal visceral fat, collected at necropsy, of human adults that lived in Siberia, one of the coldest regions of the earth. Data showed that a consistent part of the mediastinal and perirenal fat (up to about 40%) had the morphology typical of brown adipocytes and that a relevant percentage of them (up to about 30%) also expressed the functional marker uncoupling protein 1 (UCP1). Patients living mainly outdoor had higher percentage of brown-like adipocytes with more intensely UCP1 immunoreactive cells. The presence of numerous UCP1 immunoreactive paucilocular cells, a transitional stage of transdifferentiating adipocytes, supports the idea that visceral fat can be converted to brown adipose tissue in adult humans in physiological conditions. Tyrosine hydroxylase immunoreactive noradrenergic parenchymal nerve fibers were positively correlated to the number of multilocular adipocytes in mediastinal fat, and a similar trend was also observed in the perirenal fat.