Programmed Cell Death: Central Player in Fungal Infections.

Programmed Cell Death: Central Player in Fungal Infections.
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程序性细胞死亡:真菌感染的中心角色。

DOI:
10.1016/j.tcb.2020.11.005
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发表时间:
2021-03
影响因子:
19
通讯作者:
Richardson JP
Richardson JP
中科院分区:
生物学1区
文献类型:
--
作者:
Camilli G;Blagojevic M;Naglik JR;Richardson JP

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真菌疾病是人类发病率和死亡率的重要原因。虽然最近的研究已经提高了我们的理解,发生在致病真菌和人类宿主之间的复杂和动态的相互作用,仍有许多关于驱动真菌致病性和宿主对真菌感染的反应的分子机制有待阐明。近年来,研究微生物诱导的宿主细胞死亡的免疫功能的研究显著增加。此外,病原体使用许多策略来操纵宿主细胞死亡途径以促进其存活和传播。本文将重点介绍机会性真菌感染过程中宿主细胞程序性死亡的机制,并探讨细胞死亡途径如何影响对病原真菌的免疫。
Fungal diseases contribute significantly to morbidity and mortality in humans. Although recent research has improved our understanding of the complex and dynamic interplay that occurs between pathogenic fungi and the human host, much remains to be elucidated concerning the molecular mechanisms that drive fungal pathogenicity and host responses to fungal infections. In recent times, there has been a significant increase in studies investigating the immunological functions of microbial-induced host cell death. In addition, pathogens use many strategies to manipulate host cell death pathways to facilitate their survival and dissemination. This review will focus on the mechanisms of host programmed cell death that occur during opportunistic fungal infections and explore how cell death pathways may affect immunity towards pathogenic fungi.
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