Ca2+ transfer to mitochondria: a spark of life in unexpected conditions.
Ca2+ transfer to mitochondria: a spark of life in unexpected conditions.
复制标题
Ca2 转移到线粒体：意外条件下的生命火花。
DOI：
10.1080/23723556.2020.1839341
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发表时间：
2021
影响因子：
2.1
通讯作者：
Cárdenas,JulioCesar
中科院分区：
文献类型：
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作者：
Silva-Pavez,Eduardo;Ahumada-Castro,Ulises;Lovy,Alenka;Cárdenas,JulioCesar
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor mitochondria could become a feasible therapeutic target to treat tumors that depend on reductive carboxylation.
