LIMITED USEFULNESS OF HISTOPATHOLOGICAL FEATURES IN IDENTIFICATION OF A CLINICALLY AGGRESSIVE SOLID-PSEUDOPAPILLARY NEOPLASM OF THE PANCREAS
LIMITED USEFULNESS OF HISTOPATHOLOGICAL FEATURES IN IDENTIFICATION OF A CLINICALLY AGGRESSIVE SOLID-PSEUDOPAPILLARY NEOPLASM OF THE PANCREAS
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DOI：
10.5114/pjp.2014.45780
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发表时间：
2014-10-01
影响因子：
0.8
通讯作者：
Kajor, Maciej
中科院分区：
文献类型：
--
作者：
Liszka, Lukasz;Mrowiec, Slawomir;Kajor, Maciej
实性假乳头状肿瘤（SPN）是一种罕见的胰腺肿瘤。10%-15%的SPN患者在手术切除后发生远处转移和/或局部复发。在本研究中，我们的目的是系统地研究几乎所有的SPN的组织病理学特征的有用性，这些特征以前被认为是手术切除后SPN临床侵袭性行为的潜在危险因素。纳入了17个SPN。所有病例均无未分化成分。14例患者的随访数据可用（中位52个月）。1例患者在原发性肿瘤切除后17个月发生肝转移，符合临床侵袭性疾病的标准。没有一个组织病理学特征允许识别该病例，具有足够的诊断率。目前，组织病理学检查无法识别原发病灶切除后可能发生肿瘤复发的患者。应对所有接受SPN治疗的患者进行密切随访。
Solid-pseudopapillary neoplasms (SPN) are rare tumours of the pancreas. Distant metastases and/or local recurrence following surgical resection occur in 10% to 15% of patients with SPN. In the present study, we aimed to systematically examine the usefulness of virtually all histopathological features of SPN which were previously considered potential risk factors of clinically aggressive behaviour of SPN following surgical resection. Seventeen SPN were included. None of the cases had an undifferentiated component. Follow-up data were available for 14 patients (median 52 months). One patient developed liver metastasis 17 months after resection of the primary tumour and fulfilled the criteria of a clinically aggressive disease. None of the histopathological features allowed identification of that case with an adequate diagnostic yield. At present, histopathological examination cannot identify patients who may develop tumour recurrence following resection of the primary lesion. A close follow-up should be offered to all patients treated for SPN.