The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.
The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.
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DOI：
10.1371/journal.pone.0081654
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Vekrellis K
中科院分区：
文献类型：
--
作者：
Kapaki E;Paraskevas GP;Emmanouilidou E;Vekrellis K
在突触核蛋白病患者的脑脊液（CSF）中检测α-突触核蛋白（α-syn）已取得了有希望但不确定的结果。本研究的目的是在严格控制几个公认的混杂因素后，确定α-syn作为路易体痴呆（DLB）与正常受试者和阿尔茨海默病（AD）患者的生物学标志物的诊断价值。招募了16例DLB患者，18例AD患者和22例年龄和性别匹配的正常对照（CTRL）。采用新型酶联免疫吸附试验测定CSF中总α-syn水平。DLB患者CSF α-syn水平显著高于CTRL和AD组（P分别为0.049和0.01）。ROC分析显示，α-syn增加对DLB与CTRL的区分特异性为81.8%，对AD的区分特异性为90%。但敏感性较低（分别为56.2%和50%）。这些发现为α-syn作为DLB的替代生物标志物可能的诊断作用提供了证据。
The detection of α-synuclein (α-syn) in the cerebrospinal fluid (CSF) of patients with synucleinopathy has yielded promising but inconclusive results. The aim of the present study was to determine the diagnostic value of α-syn as a biological marker for Dementia with Lewy bodies (DLB) vs. normal subjects and patients with Alzheimer’s disease (AD), after strict control of several recognized confounders. Sixteen patients with DLB, 18 patients with AD and 22 age- and sex-matched normal controls (CTRL) were recruited. The levels of total α-syn in CSF were measured using a novel enzyme-linked immunosorbent assay. There was a significant increase of CSF α-syn levels in DLB patients as compared to the CTRL and AD groups (P= 0.049 and 0.01 respectively). ROC analysis revealed that increased α-syn was 81.8% specific for the discrimination of DLB vs. CTRL and 90% vs. AD. However, sensitivity was lower (56.2 % and 50% respectively). These findings provide evidence for a possible diagnostic role of α-syn as a surrogate biomarker for DLB.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
5.3
作者：
Mollenhauer, Brit;Cullen, Valerie;Schlossmacher, Michael G.
通讯作者：
Schlossmacher, Michael G.
影响因子：
11.2
作者：
MURRAY, AM;WEIHMUELLER, FB;JOYCE, JN
通讯作者：
JOYCE, JN
影响因子：
14.5
作者：
Hong, Zhen;Shi, Min;Zhang, Jing
通讯作者：
Zhang, Jing
影响因子：
11
作者：
Kasuga, Kensaku;Tokutake, Takayoshi;Ikeuchi, Takeshi
通讯作者：
Ikeuchi, Takeshi