[Changes in the megakaryocyte-platelet system in chronic neutrophilic leukemia].
[Changes in the megakaryocyte-platelet system in chronic neutrophilic leukemia].
复制标题
慢性中性粒细胞白血病巨核细胞-血小板系统的变化
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
K. Fujita
中科院分区：
文献类型：
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作者：
H. Mori;T. Ikegami;T. Shimizu;H. Harada;Y. Miyoshi;S. Okada;Y. Takizawa;H. Niikura;H. Terada;K. Fujita
对3例慢性中性粒细胞白血病(CNL)患者的血小板功能和巨核细胞形态变化进行了研究。1例出血时间延长，ADP、胶原、肾上腺素诱导的血小板聚集减少。另1例患者的血小板黏附性、肾上腺素诱导的聚集和腺苷含量下降。CNL组巨核细胞大小明显大于CML组，这种差异与巨核细胞DNA含量分布有关。1例可见不典型巨核细胞。目前的研究表明，CNL是一种干细胞疾病。
Platelet functions and morphological changes of megakaryocytes were investigated in three cases with chronic neutrophilic leukemia (CNL). The bleeding time was prolonged, the ADP, collagen, epinephrine-induced aggregation of platelets decreased in one case. The adhesiveness, epinephrine-induced aggregation and adenine nucleotide content of platelets decreased in one other case. Megakaryocyte size in CNL was larger than in CML and this difference of the megakaryocyte sizes was related to DNA content distribution of the megakaryocytes. Atypical megakaryocytes were apparently found in one case. The present study suggests that CNL is a stem cell disorder.