Simulation of multiple morphogenetic movements in the Drosophila embryo by a single 3D finite element model
Simulation of multiple morphogenetic movements in the Drosophila embryo by a single 3D finite element model
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DOI：
10.1016/j.jmbbm.2010.01.001
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Aubry, D.
中科院分区：
文献类型：
--
作者：
Allena, R.;Mouronval, A. -S.;Aubry, D.
本文描述了果蝇胚胎的三维有限元模型，旨在模拟原肠发育早期的三种形态发生运动：腹沟内陷、头沟形成和生殖带延伸。胚胎由规则椭球体表示，并且只对中胚层进行建模。此外，在一个特殊的曲线系统中，生物结构的参数描述提供了网格无关的内源应变。变形梯度分解用于将特定于每个形态发生运动的主动变形与由于连续中胚层的响应而产生的被动变形耦合在一起。边界条件，如与外卵黄膜的刚性接触和蛋黄压力也被考虑在内。结果表明，负责形态发生事件的活性菌株的数量可以少于直接实验观察得出的数量。最后，对形变过程中产生的非局域压力的估算与实验数据吻合较好。(C)2010爱思唯尔有限公司。保留所有权利。
The present work describes a 3D finite element model of the Drosophila embryo designed to simulate three morphogenetic movements during early gastrulation: ventral furrow invagination, cephalic furrow formation and germ band extension. The embryo is represented by a regular ellipsoid and only the mesoderm is modeled. Additionally, the parametric description of the biological structure in a special curvilinear system provides mesh-independent endogenous strains. A deformation gradient decomposition is used to couple an active deformation, specific for each morphogenetic movement, together with a passive deformation, which is due to the response of the continuous mesoderm. Boundary conditions such as the rigid contact with the external vitelline membrane and the yolk pressure are also taken into account. The results suggest that the number of active strains responsible for the morphogenetic events can be less than that deduced from direct experimental observations. Finally, the estimation of the non-local pressures induced during morphogenetic movements is in good agreement with the experimental data. (C) 2010 Elsevier Ltd. All rights reserved.