Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury.
Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury.
复制标题
布洛芬可减弱脓毒症引起的急性肺损伤期间血浆肿瘤坏死因子的活性。
DOI：
10.1152/jappl.1991.71.3.915
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Fowler3rd,AA
中科院分区：
文献类型：
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作者：
Leeper-Woodford,SK;Carey,PD;Byrne,K;Fisher,BJ;Blocher,C;Sugerman,HJ;Fowler3rd,AA
在300 min内监测四组麻醉猪的血浆肿瘤坏死因子（TNF）活性、心脏指数、血管外肺水、全身和肺动脉压、肺血管阻力指数和动脉PO2：盐水输注动物（n = 5），盐水输注动物（0和120 min）给予布洛芬（12.5 mg/kg iv） （n = 4），铜绿假单胞菌（Ps, 5 × 10(8)个有机体/ml， 0.3 ml.20 kg-1）输注60 min。min-1, n = 6)，以及分别于0和120 min给予Ps +布洛芬60min的动物（n = 4）。在30-60分钟内，输注Ps导致血浆TNF活性（L929细胞溶解试验）显著升高（单位/ml TNF增加4倍以上，P < 0.05），所有血流动力学和肺参数改变（P < 0.05）。在脓毒症中给予布洛芬可显著降低2单位/ml的TNF活性峰值，并减轻脓毒症引起的许多生理改变。这些结果表明，布洛芬可以减轻脓毒症引起的损伤，并且在给予布洛芬的脓毒症动物中，急性脓毒症损伤的改变与血浆TNF活性降低相关。
Plasma tumor necrosis factor (TNF) activity, cardiac index, extravascular lung water, systemic and pulmonary arterial pressures, pulmonary vascular resistance index, and arterial PO2 were monitored for 300 min in four groups of anesthetized pigs: saline-infused animals (n = 5), saline-infused animals given ibuprofen (12.5 mg/kg iv) at 0 and 120 min (n = 4), animals infused for 60 min with live Pseudomonas aeruginosa (Ps, 5 x 10(8) organisms/ml at 0.3 ml.20 kg-1.min-1, n = 6), and animals infused for 60 min with Ps plus ibuprofen administered at 0 and 120 min (n = 4). Infusion of Ps induced significant elevations (greater than 4-fold increase in units/ml of TNF by 60 min, P less than 0.05) in plasma TNF activity (L929 cytolysis assay) and alterations (P less than 0.05) in all hemodynamic and pulmonary parameters within 30–60 min. Ibuprofen administration in sepsis significantly decreased peak TNF activity by 2 units/ml and attenuated many of the physiological alterations due to sepsis. These results show that ibuprofen attenuates sepsis-induced injury and that alterations of acute septic insult are correlated with reduced plasma TNF activity in septic animals given ibuprofen.