Dietary fish oil and vitamin E enhance doxorubicin effects in P388 tumor-bearing mice
Dietary fish oil and vitamin E enhance doxorubicin effects in P388 tumor-bearing mice
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DOI：
10.1007/s11745-002-0931-1
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发表时间：
2002-06-01
期刊：
影响因子：
1.9
通讯作者：
Tan, BKH
中科院分区：
文献类型：
--
作者：
Liu, QY;Tan, BKH
本研究采用CO、FO、CVe和FVe四种啮齿动物饲料，在基础饲料AIN-93G中分别添加菜籽油、油混合物（鱼油+菜籽油）、菜籽油加维生素E、油混合物加维生素E，研究膳食鱼油和维生素E对P388腹水小鼠阿霉素（DOX）治疗的影响。记录了喂食四种不同饮食并接受不同剂量 DOX 治疗的小鼠的动物寿命 (LS) 和心脏损伤。 DOX 抗肿瘤作用的最佳剂量（表现为 LS 增加）为 6.0 和 9.0 mg/kg。鱼油和维生素 F 都显着增强了这种效果。另一方面，12.0 mg/kg DOX 会引起严重的心脏损伤，鱼油和维生素 E 也会显着加剧心脏损伤，如 LS 降低和血清肌酸磷酸激酶活性增加所示。鱼油和维生素 E 似乎可以增强最佳剂量 DOX 的抗肿瘤作用，但会加重 DOX 过量导致的心脏毒性。
In this study, four kinds of rodent diets, CO, FO, CVe, and FVe, were used by addition of canola oil, oil mixture (fish oil + canola oil), canola oil plus vitamin E, and oil mixture plus vitamin E, respectively, to a basic diet, AIN-93G, to investigate the influence of dietary fish oil and vitamin E on doxorubicin (DOX) treatment in P388 ascitic mice. Animal life span (LS) and heart damage were recorded in mice fed the four different diets and treated with different doses of DOX. The optimal doses of DOX for antitumor effect as manifested by increased LS were 6.0 and 9.0 mg/kg. Both fish oil and vitamin F significantly enhanced this effect. On the other hand, DOX at 12.0 mg/kg induced severe heart damage, which was also significantly aggravated by both fish oil and vitamin E, as shown by both decreased LS and increased serum creatine phosphokinase activity. Fish oil and vitamin E appeared to enhance the antitumor effect of optimal doses of DOX but to aggravate cardiotoxicity owing to DOX overdose.