What can be inferred from bacterium-nanoparticle interactions about the potential consequences of environmental exposure to nanoparticles?
What can be inferred from bacterium-nanoparticle interactions about the potential consequences of environmental exposure to nanoparticles?
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DOI：
10.1007/s10646-008-0217-x
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发表时间：
2008-07-01
期刊：
影响因子：
2.7
通讯作者：
Neal, Andrew L.
中科院分区：
文献类型：
--
作者：
Neal, Andrew L.
本文整理了有关金属和碳纳米颗粒体外抗菌活性的已发表信息。目的是就抗菌活性模式建立共识，并评估当前知识在预测纳米颗粒对环境暴露中重要微生物过程的可能影响方面的适用性。大多数研究表明，纳米颗粒可能会通过产生活性氧来破坏细菌膜。纳米颗粒和细菌膜之间的接触似乎是该活性得以显现所必需的。静电相互作用等界面力在这方面可能很重要。然而，源自纳米颗粒的游离金属离子的毒性不容忽视。尽管经常观察到纳米颗粒可能在膜破裂后在细胞质内积聚，但似乎不太可能穿过完整的膜。迄今为止，已发表的研究尚未旨在模仿自然系统，因此对有意或无意的环境释放可能产生的后果缺乏了解。目前有限的研究未能确定纳米颗粒在更复杂的系统中对微生物水平的任何显着影响。
This article collates published information regarding the in vitro antibacterial activity of both metal and carbon nanoparticles. The aims are to establish a consensus regarding modes of antibacterial activity, and to evaluate the applicability of current knowledge to prediction of likely effects of nanoparticles upon important microbial processes in environmental exposures. The majority of studies suggest that nanoparticles cause disruption to bacterial membranes, probably by production of reactive oxygen species. Contact between the nanoparticle and bacterial membrane appears necessary for this activity to be manifested. Interfacial forces such as electrostatic interactions are probably important in this respect. However, the toxicity of free metal ions originating from the nanoparticles cannot be discounted. Passage of nanoparticles across intact membranes appears to be unlikely, although accumulation within the cytoplasm, probably after membrane disruption, is often observed. To date, published studies have not been designed to mimic natural systems and therefore provide poor understanding of the likely consequences of intentional or unintentional environmental release. The limited studies currently available fail to identify any significant effects at the microbial level of nanoparticles in more complex systems.