Evaluating the association between endometrial cancer and polycystic ovary syndrome
Evaluating the association between endometrial cancer and polycystic ovary syndrome
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DOI：
10.1093/humrep/des042
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发表时间：
2012-05-01
影响因子：
6.1
通讯作者：
Atiomo, William
中科院分区：
文献类型：
--
作者：
Haoula, Zeina;Salman, Maisa;Atiomo, William
鉴于目前发表的文献缺乏明确性，我们对文献进行了系统回顾，以确定多囊卵巢综合征（PCOS）与子宫内膜癌（EC）之间关联的确切强度。（1966年4月2011年）、EMBASE（1980年4月2011年）和科克伦（1998年4月2011年）。提取可用的原始数据，并在单独的Microsoft Excel（2007）数据库中进行总结以供分析。共纳入14项比较和非比较研究，非比较和比较数据表明PCOS妇女更容易发生EC。一项对五项比较研究的荟萃分析显示，女性EC的风险增加，比值比为2.89，95置信区间为1.525.48。与无PCOS的女性相比，PCOS女性发生EC的可能性约为3倍。这意味着患有PCOS的白人女性患EC的终生风险为9，而无PCOS的女性为3。尽管大多数女性（91）多囊卵巢综合征不会发展为子宫内膜癌，我们的研究表明，他们更有可能增加风险。需要更多的研究来阐明确切的分子机制，确定筛查和预防疾病进展的最佳方法。
Given the current lack of clarity in the published literature, we performed a systematic review of the literature to determine the exact strength of the association between polycystic ovary syndrome (PCOS) and endometrial cancer (EC).All published studies on the association between PCOS and EC identified through MEDLINE (1966April 2011), EMBASE (1980April 2011) and Cochrane (1998April 2011). Original data were abstracted where available and summarized on a separate Microsoft Excel (2007) database for analysis. A total of 14 studies comparative and non-comparative were identified and included.The non-comparative and comparative data suggested that women with PCOS were more likely to develop EC. A meta-analyses of five comparative studies showed an increased risk of EC in women with an odds ratio of 2.89 with a 95 confidence interval of 1.525.48.Women with PCOS are about three times more likely to develop EC compared with women without it. This translates into a 9 lifetime risk of EC in Caucasian women with PCOS compared with 3 in women without it. Although most women (91) with PCOS will not develop endometrial cancer, our study has shown that they are more likely at increased risk. More studies are required to clarify the exact molecular mechanisms, determine the best way of screening and preventing disease progression.