Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease
Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease
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DOI：
10.1212/wnl.0000000000003396
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发表时间：
2016-12-06
期刊：
影响因子：
9.9
通讯作者：
Pavese, Nicola
中科院分区：
文献类型：
--
作者：
Pagano, Gennaro;Molloy, Sophie;Pavese, Nicola
目的：目的：探讨帕金森病（PD）患者下丘脑D3多巴胺受体（D3 R）活性与睡眠问题严重程度的关系。睡眠问题的严重程度用统一帕金森病评定量表第一部分的适当分项进行评定结果：我们发现，用[11 C]-PHNO PET测量的较低的多巴胺D3受体可用性与更严重的过度日间嗜睡相关，但与入睡或失眠问题无关。在我们的PD患者队列中，白天过度嗜睡的发生与下丘脑多巴胺D3受体可用性的降低有关。如果这些初步研究结果在具有多导睡眠图特征的较大患者队列中得到证实，则可以使用多巴胺能D3系统的选择性药物调节来增加PD患者的日间警觉性。
Objective: To investigate the relationship between hypothalamic D3 dopamine receptor availability and severity of sleep problems in Parkinson disease (PD).Methods: Twelve patients were assessed with PET and the high-affinity dopamine D3 receptor radioligand [C-11]-propyl-hexahydro-naphtho-oxazin ([C-11]-PHNO). Severity of sleep problems was rated with appropriate subitems of the Unified Parkinson's Disease Rating Scale part I (patient questionnaire) and the Epworth Sleepiness Scale.Results: We found that lower dopamine D3 receptor availability measured with [11C]-PHNO PET was associated with greater severity of excessive daytime sleepiness but not with problems of falling asleep or insomnia.Conclusion: In our cohort of patients with PD, the occurrence of excessive daytime sleepiness was linked to reductions in hypothalamic dopamine D3 receptor availability. If these preliminary findings are confirmed in larger cohorts of patients with polysomnographic characterization, selective pharmacologic modulation of the dopaminergic D3 system could be used to increase daytime alertness in patients with PD.