Poly(ϵ‐caprolactone)‐Functionalized Carbon Nanotubes and Their Biodegradation Properties
Poly(ϵ‐caprolactone)‐Functionalized Carbon Nanotubes and Their Biodegradation Properties
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DOI：
10.1002/adfm.200500607
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发表时间：
2006-04
影响因子：
19
通讯作者：
Hailin Zeng;Chao Gao;D. Yan
中科院分区：
文献类型：
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作者：
Hailin Zeng;Chao Gao;D. Yan
可生物降解的聚（柱‐己内酯）（PCL）已被共价接枝到多壁碳纳米管（MWNTs）的表面上，这种接枝方法是基于原位开环聚合的柱‐己内酯。通过调整单体与MWNT - OH载体的投料比，可以很容易地控制接枝PCL的含量。所得产物已通过傅里叶变换红外（FTIR）、核磁共振（NMR）和拉曼光谱（Raman）、透射电子显微镜（TEM）和扫描电子显微镜（SEM）进行了表征。将PCL包覆在MWNT表面后，形成了以纳米管为“硬”核、以毛状聚合物层为“软”壳的核/壳结构，特别是包覆高密度聚合物链的MWNT。这种聚合物外壳保证了MWNT-PCL纳米杂化物在氯仿和四氢呋喃等低沸点有机溶剂中的良好溶解度/分散性。生物降解实验表明，在磷酸缓冲液中，在假单胞菌（PS）脂肪酶的作用下，接枝的PCL可以在4天内被完全酶降解，并且通过扫描电镜和透射电镜观察到碳纳米管仍保持管状形态。研究结果表明，这些具有生物相容性的PCL功能化碳纳米管在生物纳米材料、生物医学和人工骨中的应用前景广阔。
Biodegradable poly(ϵ‐caprolactone) (PCL) has been covalently grafted onto the surfaces of multiwalled carbon nanotubes (MWNTs) by the “grafting from” approach based on in‐situ ring‐opening polymerization of ϵ‐caprolactone. The grafted PCL content can be controlled easily by adjusting the feed ratio of monomer to MWNT‐supported macroinitiators (MWNT‐OH). The resulting products have been characterized with Fourier‐transform IR (FTIR), NMR, and Raman spectroscopies, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). After PCL was coated onto MWNT surfaces, core/shell structures with nanotubes as the “hard” core and the hairy polymer layer as the “soft” shell are formed, especially for MWNTs coated with a high density of polymer chains. Such a polymer shell promises good solubility/dispersibility of the MWNT–PCL nanohybrids in low‐boiling‐point organic solvents such as chloroform and tetrahydrofuran. Biodegradation experiments have shown that the PCL grafted onto MWNTs can be completely enzymatically degraded within 4 days in a phosphate buffer solution in the presence of pseudomonas (PS) lipase, and the carbon nanotubes retain their tubelike morphologies, as observed by SEM and TEM. The results present possible applications for these biocompatible PCL‐functionalized CNTs in bionanomaterials, biomedicine, and artificial bones.