Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris.
Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris.
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DOI：
10.3390/microorganisms9030634
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发表时间：
2021-03-18
期刊：
影响因子：
4.5
通讯作者：
Jawhara S
中科院分区：
文献类型：
--
作者：
Billamboz M;Fatima Z;Hameed S;Jawhara S
侵袭性真菌感染对公共卫生构成日益严重的威胁。在过去的十年中，随着耳念珠菌的出现，念珠菌病从白色念珠菌到非白色念珠菌的范式转变已经从根本上增加。C. auris于2009年被确认，现在被认为是一个令人关切的新物种，并强调迫切需要新的药物开发战略。本文就近年来国内外对克雷伯氏菌的基因组流行病学及主要毒力因子的研究进展作一综述。耳。我们还重点介绍了在过去十年中针对这种新兴的C.耳病原酵母菌，基于药物化学的观点。化学特征和物理化学描述符的批判性分析将与报告策略的描述一起进行沿着。
Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from Candida albicans to non-albicans Candida species has fundamentally increased with the advent of Candida auris. C. auris was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of C. auris. We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging C. auris pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.
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影响因子：
4.9
作者：
Arendrup, Maiken Cavling;Chowdhary, Anuradha;Jorgensen, Karin Meinike
通讯作者：
Jorgensen, Karin Meinike
影响因子：
4.5
作者：
Cadnum, Jennifer L.;Shaikh, Aaron A.;Donskey, Curtis J.
通讯作者：
Donskey, Curtis J.
DOI：
10.1016/j.ijantimicag.2020.106049
发表时间：
2020-08-01
影响因子：
10.8
作者：
Barreto, Thayna Lopes;Rossato, Luana;Ishida, Kelly
通讯作者：
Ishida, Kelly
影响因子：
38.9
作者：
Chakrabarti, Arunaloke;Sood, Prashant;Mendiratta, Deepak
通讯作者：
Mendiratta, Deepak
影响因子：
4.9
作者：
Basso, Virginia;Garcia, Angie;Selsted, Michael E.
通讯作者：
Selsted, Michael E.