Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS03-21
Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS03-21
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来自耐酸真菌Penicillium purpurogenum JS03-21的抗流感病毒聚酮化合物
DOI：
10.1021/np2004769
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发表时间：
2011-09-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
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作者：
Wang, Hui;Wang, Yi;Zhu, Weiming
从耐酸真菌产紫青霉（PenicilliumpurpurogenumJS 03 -21）的乙酸乙酯提取物中分离出6个新化合物，即紫醌A-C（1-3），紫酯A和B（4和5），2，6，7-三羟基-3-甲基萘-1，4-二酮（6），以及3个已知化合物TAN-931（7），（-）-mitoruridine（8），和地衣酸。化合物1-6的结构经核磁共振实验初步鉴定。根据CD和NOESY数据对1-4的绝对构型进行了归属。化合物2-4和7显示出显著的抗H1N1病毒活性，IC（50）值分别为61.3、64.0、85.3和58.6 μ M。
Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A-C (1-3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (-)-mitorubrin (8), and orsellinic acid. The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned on the basis of CD and NOESY data. Compounds 2-4 and 7 exhibited significant antiviral activity against H1N1, with IC(50) values of 61.3, 64.0, 85.3, and 58.6 mu M, respectively.