Kinetic selection of template polymer with complex sequences
Kinetic selection of template polymer with complex sequences
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具有复杂序列的模板聚合物的动力学选择
DOI：
10.1103/physrevlett.121.118101
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Y. J. Matsubara and K. Kaneko
中科院分区：
文献类型：
--
作者：
岡本 晃一;立石 和隆;川元 駿;西田 知句;玉田 薫;船戸 充;川上 養一;岡田裕貴;Y. J. Matsubara and K. Kaneko
具有复杂序列的聚合物的出现和维持提出了生命起源研究中的一个主要问题。为了回答这个问题，我们研究了一种模型聚合反应，其中聚合物是通过两种类型的单体逐步连接合成的，并由长聚合物作为模板催化。直接随机模拟和动力系统分析表明，群体中最主要的聚合物序列会根据单体进入系统的流速而连续变化，并在较低流速下选择更复杂的序列。我们讨论了这种通过非平衡流动的动力学序列选择与复杂聚合物起源的相关性。
The emergence and maintenance of polymers with complex sequences pose a major question in the study of the origin of life. To answer this, we study a model polymerization reaction, where polymers are synthesized by stepwise ligation from two types of monomers, catalyzed by a long polymer as a template. Direct stochastic simulation and dynamical systems analysis reveal that the most dominant polymer sequence in a population successively changes, depending on the flow rate of monomers to the system, with more complex sequences selected at a lower flow rate. We discuss the relevance of this kinetic sequence selection through nonequilibrium flow to the origin of complex polymers.