Alpha‐interferon therapy for chronic hepatitis B virus infection in children and Oriental patients
Alpha‐interferon therapy for chronic hepatitis B virus infection in children and Oriental patients
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α-干扰素治疗儿童和东方患者慢性乙型肝炎病毒感染
DOI：
10.1111/j.1440-1746.1991.tb01160.x
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发表时间：
1991
影响因子：
4.1
通讯作者：
A. Lok
中科院分区：
文献类型：
--
作者：
A. Lok
总之，这四项研究表明，α-IFN单独治疗对少数慢性HBV感染的中国成年人产生持续的HBV复制抑制作用。在较早的年龄开始治疗并没有改善这种反应。中国患者应答差的主要原因可能是早期暴露于HBV导致的免疫耐受。治疗前血清ALT水平升高的中国患者（可能存在持续的感染肝细胞内源性免疫溶解）的应答显著优于白人患者，且与白人患者报告的应答相当。在治疗前血清ALT水平正常的患者中，泼尼松预充与单独使用IFN治疗相比没有任何额外的优势，但在ALT水平升高的患者中似乎有额外的益处。
In summary, these four studies showed that alpha-IFN therapy alone produced sustained inhibition of HBV replication in a minority of Chinese adults with chronic HBV infection. The response was not improved by instituting treatment at an earlier age. The major reason for the poor response in Chinese patients is probably immune tolerance as a result of early exposure to HBV. The response in Chinese patients with elevated pre-treatment serum ALT levels, who presumably had ongoing endogenous immune lysis of infected hepatocytes, was significantly better than and comparable with that reported in Caucasian patients. Prednisone priming did not provide any additional advantage over therapy with IFN alone in patients with normal pre-treatment serum ALT levels, but appeared to have additional benefit in patients with elevated ALT levels.