Additive effects of acupuncture in alleviating anxiety: A double-blind, three-arm, randomized clinical trial
Additive effects of acupuncture in alleviating anxiety: A double-blind, three-arm, randomized clinical trial
复制标题
DOI：
10.1016/j.ctcp.2021.101466
复制
发表时间：
2021-08-10
影响因子：
3
通讯作者：
Khorsand, Ali
中科院分区：
文献类型：
--
作者：
Gol, Ali Sabbagh;Ardani, Amir Rezaei;Khorsand, Ali
工作背景：在这项试验中，针灸的选择性5-羟色胺再摄取抑制剂（SSRIs）治疗，以减少焦虑的累加效应，进行了调查。研究方法：将112例焦虑症患者随机分为单纯SSRI组（药物组）、SSRI+假针组（对照组）和SSRI+针刺组（针刺组），治疗4周。在研究开始时和第28天，完成Spielberger状态-特质焦虑量表（STAI）问卷并测量血清皮质醇水平。结果：105例患者完成了治疗期。研究结束时，三组之间的STAI评分显示出显著差异;重要的是，针刺组的STAI评分变化显著大于其他组。在所有组中均观察到皮质醇水平下降;尽管统计学上不显著，但针刺组的下降幅度更大。结论：针刺联合SSRIs治疗焦虑症较单用SSRIs治疗焦虑症疗效显著。
Background: In this trial, additive effects of acupuncture to selective serotonin reuptake inhibitors (SSRIs) treatment for reducing anxiety, were investigated. Methods: 112 patients with anxiety disorder were randomly divided into three groups including SSRIs alone (drug group), SSRIs with sham acupuncture (control group) and SSRI with acupuncture (acupuncture group), and treated for 4 weeks. At the beginning of the study and on day 28, Spielberger State-Trait Anxiety Inventory (STAI) questionnaire was completed and serum levels of cortisol were measured. Results: 105 patients completed the treatment period. STAI score showed significant differences among the three groups at the end of the study; importantly, changes in STAI score in the acupuncture group were significantly larger than the other groups. A decrease in cortisol levels was observed in all groups; though statistically nonsignificant, this decrease in the acupuncture group was larger. Conclusion: Acupuncture combined with SSRIs can significantly improve anxiety state compared to anti-anxiety therapy using SSRIs alone.