Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer's Disease
Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer's Disease
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DOI：
10.3233/jad-161067
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发表时间：
2017-01-01
影响因子：
4
通讯作者：
Okonkwo, Ozioma C.
中科院分区：
文献类型：
--
作者：
Doughertya, Ryan J.;Schultz, Stephanie A.;Okonkwo, Ozioma C.
本研究的目的是探讨无症状中老年人的加速计测量的体力活动(PA)与糖代谢的关系。来自威斯康星州阿尔茨海默病预防登记处的93名认知健康的中晚期成年人参与了这项横断面研究。他们接受18F-脱氧葡萄糖正电子发射断层扫描(FDG-PET)成像，并佩戴加速度计(Actigraph GT3X+)测量自由生活的PA。加速度计数据得到了光(LPA)、中等(Mpa)和强(VPA)强度PA的测量结果。将FDG-PET图像缩放到小脑和桥脑，从已知AD患者代谢低下的特定感兴趣区(ROI)提取大脑葡萄糖代谢率，即海马区、后扣带区、下颞叶皮质和角回。回归分析被用来检验PA和葡萄糖代谢之间的关联，同时调整潜在的混杂因素。在所有被检查的感兴趣区中，MPA与糖代谢有关。相反，LPA在任何ROI中都与葡萄糖摄取无关，而VPA仅与海马区FDG摄取相关。二次分析没有发现任何ROI患者的久坐时间和葡萄糖代谢之间的关联。探索性体素分析发现了其他与糖代谢显著相关的区域，包括楔前回、缘上回、杏仁核和额中回。这些发现表明，PA的强度是中晚期队列中神经元功能的重要贡献因素，其中以MPA最为显著。为了充分阐明中年参与PA与AD后期发展之间的联系，前瞻性研究是必要的。
The objective of this study was to investigate the relationship between accelerometer-measured physical activity (PA) and glucose metabolism in asymptomatic late-middle-aged adults. Ninety-three cognitively healthy late-middle-aged adults from the Wisconsin Registry for Alzheimer's Prevention participated in this cross-sectional study. They underwent 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and wore an accelerometer (ActiGraph GT3X+) to measure free-living PA. Accelerometer data yielded measures of light (LPA), moderate (MPA), and vigorous (VPA) intensity PA. FDG-PET images were scaled to the cerebellum and pons, and cerebral glucose metabolic rate was extracted from specific regions of interest (ROIs) known to be hypometabolic in AD, i.e., hippocampus, posterior cingulate, inferior temporal cortex, and angular gyrus. Regression analyses were utilized to examine the association between PA and glucose metabolism, while adjusting for potential confounds. There were associations between MPA and glucose metabolism in all ROIs examined. In contrast, LPA was not associated with glucose uptake in any ROI and VPA was only associated with hippocampal FDG uptake. Secondary analyses did not reveal associations between sedentary time and glucose metabolism in any of the ROIs. Exploratory voxel-wise analysis identified additional regions where MPA was significantly associated with glucose metabolism including the precuneus, supramarginal gyrus, amygdala, and middle frontal gyrus. These findings suggest that the intensity of PA is an important contributor to neuronal function in a late-middle-aged cohort, with MPA being the most salient. Prospective studies are necessary for fully elucidating the link between midlife engagement in PA and later life development of AD.