Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men
Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men
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DOI：
10.1152/ajpregu.00290.2005
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发表时间：
2005-10-01
影响因子：
2.8
通讯作者：
Feinle-Bisset, C
中科院分区：
文献类型：
--
作者：
Little, TJ;Feltrin, KL;Feinle-Bisset, C
我们最近报道，十二指肠内输注月桂酸（C12）（0.375 kcal/min，106 mM）刺激孤立的幽门压力波（IPPW），抑制胃窦和十二指肠压力波（PW），刺激胆囊收缩素（CCK）和胰高血糖素样肽-1（GLP-1）的释放，并抑制能量摄入，并且这些作用远大于对异卡路里癸酸（C10）输注的反应。然而，C12给药与恶心相关，混淆了结果的解释。本研究的目的是评价不同十二指肠内剂量的C12对胃窦十二指肠（APD）运动、血浆CCK和GLP-1浓度、食欲和能量摄入的影响。以双盲、随机化方式对13名健康男性进行了为期4天的研究。在90分钟ID输注0.1（14 mM）、0.2（28 mM）或0.4（56 mM）kcal/min的C12或生理盐水（对照;速率4 ml/min）期间，测量APD压力、血浆CCK和GLP-1浓度以及食欲感知。输注后立即在自助餐中测定能量摄入。C12呈剂量依赖性地刺激IPPWs，降低胃窦和十二指肠运动，刺激CCK和GLP-1的分泌（r > 0.4，P均< 0.05）。与对照组、C12（0.1 kcal/min）和C12（0.2 kcal/min）相比，C12（0.4 kcal/min）抑制能量摄入（P < 0.05）。在无恶心的情况下观察到这些效应。总之，十二指肠内C12剂量依赖性地调节健康男性受试者的APD运动和胃肠激素释放，而对能量摄入的影响仅在输注最高剂量（0.4 kcal/min）时才明显，可能是因为仅在该剂量下调节APD运动和胃肠激素分泌足以抑制能量摄入。
We recently reported that intraduodenal infusion of lauric acid (C12) (0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs), stimulates release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and suppresses energy intake and that these effects are much greater than those seen in response to isocaloric decanoic acid (C10) infusion. Administration of C12 was, however, associated with nausea, confounding interpretation of the results. The aim of this study was to evaluate the effects of different intraduodenal doses of C12 on antropyloroduodenal (APD) motility, plasma CCK and GLP-1 concentrations, appetite, and energy intake. Thirteen healthy males were studied on 4 days in double-blind, randomized fashion. APD pressures, plasma CCK and GLP-1 concentrations, and appetite perceptions were measured during 90-min ID infusion of C12 at 0.1 (14 mM), 0.2 (28 mM), or 0.4 (56 mM) kcal/min or saline (control; rate 4 ml/min). Energy intake was determined at a buffet meal immediately following infusion. C12 dose-dependently stimulated IPPWs, decreased antral and duodenal motility, and stimulated secretion of CCK and GLP-1 (r > 0.4, P < 0.05 for all). C12 (0.4 kcal/min) suppressed energy intake compared with control, C12 (0.1 kcal/min), and C12 (0.2 kcal/min) (P < 0.05). These effects were observed in the absence of nausea. In conclusion, intraduodenal C12 dose-dependently modulated APD motility and gastrointestinal hormone release in healthy male subjects, whereas effects on energy intake were only apparent with the highest dose infused (0.4 kcal/min), possibly because only at this dose was modulation of APD motility and gastrointestinal hormone secretion sufficient for a suppressant effect on energy intake.