Congenital cytomegalovirus infection and hearing loss.
Congenital cytomegalovirus infection and hearing loss.
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发表时间：
2005-10
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通讯作者：
R. Pass
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作者：
R. Pass
感音神经性听力损失是先天性巨细胞病毒（CMV）感染最常见的后遗症，流行病学证据也表明先天性巨细胞病毒感染是儿童感音神经性听力损失的主要原因。先天性巨细胞病毒感染导致的听力损失可以在出生时出现，也可以在出生后出现，通常在出生后的第一年；它通常随着婴儿或儿童年龄的增长而恶化。先天性巨细胞病毒感染儿童的随访应包括反复的听力学检查。基于早期发现听力损失的好处，可以建议对所有婴儿进行先天性巨细胞病毒感染筛查，以便通过适当的听力学随访尽早发现听力障碍。抗病毒治疗可以改善听力结果，并且具有安全性，适合用于轻度患病婴儿，这将明显增加先天性巨细胞病毒感染普遍筛查的益处。
Sensorineural hearing loss is the most frequent sequela of congenital cytomegalovirus (CMV) infection, and epidemiological evidence also suggests that congenital CMV infection is responsible for a substantial proportion of sensorineural hearing loss in children. Hearing loss due to congenital CMV infection can be present at birth or can appear later, usually during the first year of life; it usually worsens as the infant or child ages. Follow-up of children with congenital CMV infection should include repeated audiological testing. Based on the benefits of early detection of hearing loss, one could propose screening all infants for congenital CMV infection so that those with hearing impairment can be identified as early as possible by appropriate audiological follow-up. Antiviral treatment that could improve hearing outcome, with a safety profile suitable for use in minimally ill infants, would clearly increase the benefit of universal screening for congenital CMV infection.