Regulation of alphaherpesvirus protein via post-translational phosphorylation.
Regulation of alphaherpesvirus protein via post-translational phosphorylation.
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DOI：
10.1186/s13567-022-01115-z
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发表时间：
2022-11-17
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
甲疱疹病毒的囊膜、被膜和衣壳结构中携带数十种病毒蛋白，每种蛋白在病毒吸附、入侵、脱壳和释放过程中发挥着不可或缺的作用。病毒感染宿主后，通过多种机制消除不利因素，逃避或抑制宿主免疫系统的攻击。蛋白质的翻译后修饰，尤其是磷酸化修饰，通过一系列复杂的机制调控蛋白质构象和生物活性的变化。许多病毒已经进化出利用宿主磷酸化系统来调节病毒蛋白质活性并为有效的病毒复制和毒力建立合适的细胞环境的机制。在本文中，病毒蛋白激酶和调节病毒蛋白功能介导的磷酸化的α疱疹病毒蛋白质。此外，本文还为进一步研究病毒蛋白的翻译后修饰在病毒生命周期中的作用提供了新的思路，这将有助于理解病毒感染宿主的机制，并可能为抗病毒治疗提供新的方向。
An alphaherpesvirus carries dozens of viral proteins in the envelope, tegument and capsid structure, and each protein plays an indispensable role in virus adsorption, invasion, uncoating and release. After infecting the host, a virus eliminates unfavourable factors via multiple mechanisms to escape or suppress the attack of the host immune system. Post-translational modification of proteins, especially phosphorylation, regulates changes in protein conformation and biological activity through a series of complex mechanisms. Many viruses have evolved mechanisms to leverage host phosphorylation systems to regulate viral protein activity and establish a suitable cellular environment for efficient viral replication and virulence. In this paper, viral protein kinases and the regulation of viral protein function mediated via the phosphorylation of alphaherpesvirus proteins are described. In addition, this paper provides new ideas for further research into the role played by the post-translational modification of viral proteins in the virus life cycle, which will be helpful for understanding the mechanisms of viral infection of a host and may lead to new directions of antiviral treatment.
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影响因子：
3.7
作者：
Kim S;Ahn BC;O'Callaghan DJ;Kim SK
通讯作者：
Kim SK
影响因子：
5.5
作者：
Chen L;Kashina A
通讯作者：
Kashina A
DOI：
10.1073/pnas.200375297
发表时间：
2000-09-26
影响因子：
11.1
作者：
Advani, SJ;Weichselbaum, RR;Roizman, B
通讯作者：
Roizman, B
影响因子：
5.4
作者：
Dauber, Bianca;Pelletier, Jerry;Smiley, James R.
通讯作者：
Smiley, James R.
影响因子：
5.4
作者：
Davido, DJ;von Zagorski, WF;Schaffer, PA
通讯作者：
Schaffer, PA