Cholesterol's Function and Origin in the Alzheimer's Disease Brain.
Cholesterol's Function and Origin in the Alzheimer's Disease Brain.
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DOI：
10.3233/jad-230538
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发表时间：
2023-06
期刊：
影响因子：
--
通讯作者：
S. Hansen
中科院分区：
文献类型：
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作者：
S. Hansen
阿尔茨海默病（AD）是一种与神经炎症和脑中脂质改变相关的神经退行性疾病。胆固醇是炎症脂质的关键成分。然而，胆固醇在AD中的作用，特别是在散发性或迟发性AD中，由于认为大多数脑胆固醇与循环血液胆固醇是分开的，因此仍然知之甚少。一种新的理论表明，循环胆固醇渗透到大脑中是AD发病的关键原因。随着这一领域研究的继续，预计将出现新的假设和见解。
Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuroinflammation and altered lipids in the brain. Cholesterol is a key component of inflammatory lipids. However, the role of cholesterol in AD, specifically in sporadic or late-onset AD, has remained poorly understood due to the belief that most brain cholesterol is separate from circulating blood cholesterol. A new theory suggests that the permeation of circulating cholesterol into the brain is a causal event critical for the onset of AD. As research in this area continues, new hypotheses and insights into AD are expected to emerge.