Temporal components of the motor patterns expressed by the human spinal cord reflect foot kinematics
Temporal components of the motor patterns expressed by the human spinal cord reflect foot kinematics
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DOI：
10.1152/jn.00223.2003
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发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Lacquaniti, F
中科院分区：
文献类型：
--
作者：
Ivanenko, YP;Grasso, R;Lacquaniti, F
人类脊髓构建运动模式的构件是什么？原则上，它们可以对应数十种不同肌肉的每种单独的活动模式。或者，可能存在一小组所有激活模式所共有的组成时间分量，并反映全局运动学目标。为了解决这个问题，我们研究了接受过体重支撑的跑步机训练的脊柱损伤患者。患者学会了产生与健康受试者相似的足部运动学，但个体肌肉的活动模式通常与对照组不同。隐藏在肌肉模式中，我们发现了一组基本的五个时间成分，它们的灵活组合解释了对照组和患者记录的广泛肌肉模式。此外，其中两个组件与不同步速和负载条件下的足部运动学系统相关。我们认为这些成分与脊髓模式发生器输出的控制信号有关，通常受到下行和传入输入的影响。
What are the building blocks with which the human spinal cord constructs the motor patterns of locomotion? In principle, they could correspond to each individual activity pattern in dozens of different muscles. Alternatively, there could exist a small set of constituent temporal components that are common to all activation patterns and reflect global kinematic goals. To address this issue, we studied patients with spinal injury trained to step on a treadmill with body weight support. Patients learned to produce foot kinematics similar to that of healthy subjects but with activity patterns of individual muscles generally different from the control group. Hidden in the muscle patterns, we found a basic set of five temporal components, whose flexible combination accounted for the wide range of muscle patterns recorded in both controls and patients. Furthermore, two of the components were systematically related to foot kinematics across different stepping speeds and loading conditions. We suggest that the components are related to control signals output by spinal pattern generators, normally under the influence of descending and afferent inputs.