The management of radiation-induced brain injury.
The management of radiation-induced brain injury.
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DOI：
10.1007/0-387-25354-8_2
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发表时间：
2006
影响因子：
--
通讯作者：
E. Shaw;M. Robbins
中科院分区：
文献类型：
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作者：
E. Shaw;M. Robbins
中枢神经系统（CNS）的肿瘤是一组病理学上多样化的良性和恶性肿瘤，对其采用各种管理策略，包括观察、手术、放射治疗和/或化疗。表1所示为用于治疗原发性和转移性脑和脊髓肿瘤的常用放射剂量，其涵盖了广泛的总剂量和每部分剂量。无论治疗的CNS肿瘤的类型如何，通常限制可以使用的辐射剂量的因素，以及因此通常决定该肿瘤的局部控制和治愈率的因素是CNS中和周围的相邻或下层正常组织的耐受剂量。本章将概述中枢神经系统辐射耐受性的生物学和临床原则以及辐射诱导的中枢神经系统损伤的管理。
Neoplasms of the central nervous system (CNS) are a pathologically diverse group of benign and malignant tumors for which a variety of management strategies, including observation, surgery, radiation therapy, and/or chemotherapy, are employed. Shown in Table 1 are the usual radiation doses used to treat primary and metastatic brain and spinal cord tumors, which span a broad range of total doses and doses per fraction. Regardless of the type of CNS tumor treated, what usually limits the dose of radiation that can be utilized, and therefore what typically determines the local control and cure rate of that tumor, are the tolerance doses of the adjacent or underlying normal tissues in and around the CNS. This chapter will outline the biologic and clinical principles of CNS radiation tolerance and the management of radiation-induced CNS injury.