Clinical epidemiology of invasive cutaneous malignant melanoma in the Austrian province styria in the years 2001-2003 and its relationship with local geographical, meteorological and economic data
Clinical epidemiology of invasive cutaneous malignant melanoma in the Austrian province styria in the years 2001-2003 and its relationship with local geographical, meteorological and economic data
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DOI：
10.1159/000099590
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发表时间：
2007-01-01
期刊：
影响因子：
3.4
通讯作者：
Smolle, Josef
中科院分区：
文献类型：
--
作者：
Richtig, Erika;Berghold, Andrea;Smolle, Josef
背景：黑色素瘤的发病率在欧洲各不相同。据报告，斯堪的纳维亚的发病率最高，南部地区最低，但不同国家的发病率也各不相同。目的：我们调查了2001-2003年奥地利施蒂里亚省侵袭性皮肤黑色素瘤的发病率。方法：收集了1,082例原发性黑色素瘤患者的数据，其中男性511例，女性571例（平均年龄58.2岁）。对于每例患者，可获得有关居住地的信息，因此，特别参考平均日照时数、平均海拔高度、员工超过200人的公司数量和收入中位数，研究了黑素瘤在地区一级的地理分布。结果：平均年发病率（年龄标准化率）为24.5/100，000（95%CI：22.4-26.6），终生风险为1/52。日照时间和海拔较高的地区黑色素瘤发病率较低。较高的中位收入与较高的黑色素瘤发病率相关（p < 0.001）。结论：施蒂里亚的侵袭性黑色素瘤的高发病率尚不清楚，高收入和黑色素瘤发病率之间的因果关系仍是推测性的。进一步的调查，特别是关于生活方式和环境因素的调查，可能会揭示更多的致病因素。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Melanoma incidence rates vary within Europe. The highest incidences are reported in Scandinavia, the lowest in the southern parts, but incidences themselves also vary within the different countries. Objective: We investigated the incidence of invasive cutaneous melanoma in Styria, a province of Austria, in the years 2001-2003. Methods: Data from 1,082 patients, 511 males and 571 females (mean age 58.2 years) with primary melanoma were collected. For each patient, information regarding residence was available, and therefore the geographic distribution of melanoma on district level was investigated with particular reference to the mean number of sun hours, mean altitude, number of companies with more than 200 employees and median income. Results: The mean annual incidence (age-standardized rate) was 24.5 per 100,000 (95% CI: 22.4-26.6), lifetime risk 1 in 52. Districts with a higher number of sun hours and higher altitude showed lower melanoma incidences. Higher median income was associated with higher melanoma incidence (p < 0.001). Conclusion: The high incidence of invasive melanoma in Styria is unclear and a causal relationship between higher income and melanoma incidence remains speculative. Further investigations, especially concerning lifestyle and environmental factors, may unravel additional causative factors. Copyright (c) 2007 S. Karger AG, Basel.