Surface, corrosion and biocompatibility aspects of Nitinol as an implant material.
Surface, corrosion and biocompatibility aspects of Nitinol as an implant material.
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发表时间：
2002
影响因子：
1
通讯作者：
S. Shabalovskaya
中科院分区：
文献类型：
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作者：
S. Shabalovskaya
本综述调查的物理化学性能和生物组织的生物反应，镍钛合金（镍钛合金）最近进行的研究，旨在了解这种材料的植入物合金中使用的位置。形状记忆和超弹性的优点进行了分析方面的功能植入物在体内。分析了表面处理、灭菌程序和所得表面条件的各种方法。还对在各种腐蚀介质和实际体液中使用动电位和恒电位技术对锻造和铸态合金进行的腐蚀研究进行了综述。给出了局部腐蚀和电偶腐蚀的参数。分析了合金成分、相态、表面处理和应变等方面的腐蚀行为，并与传统植入物合金进行了比较。在了解多孔镍钛合金表面状况和腐蚀行为的基础上，分析了多孔镍钛合金的生物相容性、镍的释放及其对活细胞的影响。此外，该论文还简要概述了常用医用合金的金属组分的比较毒性，表明镍钛诺的生物相容性特征有利于目前的体内应用。
The present review surveys studies on physical-chemical properties and biological response of living tissues to NiTi (Nitinol) carried out recently, aiming at an understanding of the place of this material among the implant alloys in use. Advantages of shape memory and superelasticity are analyzed in respect to functionality of implants in the body. Various approaches to surface treatment, sterilization procedures, and resulting surface conditions are analyzed. A review of corrosion studies conducted both on wrought and as-cast alloys using potentiodynamic and potentiostatic techniques in various corrosive media and in actual body fluids is also given. The parameters of localized and galvanic corrosion are presented. The corrosion behavior is analyzed with respect to alloy composition, phase state, surface treatment, and strain and compared to that of conventional implant alloys. Biocompatibility of porous Nitinol, Ni release and its effect on living cells are analyzed based on understanding of the surface conditions and corrosion behavior. Additionally, the paper offers a brief overview of the comparative toxicity of metals, components of commonly used medical alloys, indicating that the biocompatibility profile of Nitinol is conducive to present in vivo applications.