Active dendritic currents gate descending cortical outputs in perception
Active dendritic currents gate descending cortical outputs in perception
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DOI：
10.1038/s41593-020-0677-8
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发表时间：
2020-08-03
影响因子：
25
通讯作者：
Larkum, Matthew E.
中科院分区：
文献类型：
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作者：
Takahashi, Naoya;Ebner, Christian;Larkum, Matthew E.
皮质柱的输出通过不同的路径被传送到不同的下游目标：皮质-皮质和皮质下-皮质。目前还不清楚这些通路在感知中扮演什么角色，以及哪些细胞和电路机制调节它们的门控。我们最近发现，第5层(L5)锥体神经元顶端树突的激活与感知阈值有关，但这些神经元分为两类，分别针对其他皮质或皮质下区域。在本研究中，我们利用这些L5亚类的转基因小鼠品系来确定它们对知觉过程的相对贡献。我们发现，投射到皮质下区域的躯体感觉皮质神经元顶端树突的激活几乎完全决定了小鼠对触觉刺激的检测。我们的结果表明，树突的激活推动了皮质和皮质下区域之间的上下文相关的相互作用，包括对知觉至关重要的高阶丘脑、上丘和纹状体。作者发现，感知时刻与皮质下投射到高阶丘脑、上丘和纹状体的第5层锥体神经元的树突活动有因果关系。
The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical dendrites of layer 5 (L5) pyramidal neurons correlates with the threshold for perception, but these neurons come in two classes that target either other cortical or subcortical areas. In the present study, we took advantage of transgenic mouse lines for these L5 subclasses to determine their relative contributions to the perceptual process. We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice. Our results suggest that dendritic activation drives context-dependent interactions between cortex and subcortical regions, including the higher-order thalamus, superior colliculus and striatum, which are crucial for perception.The authors showed that the 'moment of perception' is causally related to dendritic activity in subcortically projecting layer 5 pyramidal neurons that project to the higher-order thalamus, superior colliculus and striatum.