DIDEMNINS - ANTI-VIRAL AND ANTI-TUMOR DEPSIPEPTIDES FROM A CARIBBEAN TUNICATE
DIDEMNINS - ANTI-VIRAL AND ANTI-TUMOR DEPSIPEPTIDES FROM A CARIBBEAN TUNICATE
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DOI：
10.1126/science.7233187
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
LI, LH
中科院分区：
文献类型：
--
作者：
RINEHART, KL;GLOER, JB;LI, LH
海鞘科加勒比被囊动物[trididemum sp.]（海鞘，海鞘）样品的提取物在体外低浓度抑制DNA和RNA病毒[单纯疱疹1型和2型，流感，副流感，柯萨奇a -21和马鼻病毒]以及L1210白血病[小鼠]细胞的生长。从被囊动物中分离出的活性化合物didemnins A、B和C是沉积肽，didemnins B （didemnins A的衍生物）是体外抑制病毒复制和体内抑制P388白血病[小鼠]活性最低的成分。
Extracts of samples of a Caribbean tunicate [Trididemnum sp.] (ascidian, sea squirt) of the family Didemnidae inhibit in vitro at low concentrations the growth of DNA and RNA viruses [herpes simplex types 1 and 2, influenza, parainfluenza, Coxsackie A-21 and equine rhinovirus] as well as L1210 leukemic [mouse] cells. The active compounds isolated from the tunicate, didemnins A, B and C, are depsipeptides, and didemnin B (a derivative of didemnin A) is the component active at the lowest concentration in inhibiting viral replication in vitro and P388 leukemia [mouse] in vivo.