Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers
Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers
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DOI：
10.1039/b309487a
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发表时间：
2003-01-01
影响因子：
4.9
通讯作者：
Goh, S
中科院分区：
文献类型：
--
作者：
Liu, Y;Wu, DC;Goh, S
通过三功能胺单体与二丙烯酸酯的Michael加成聚合，获得了一种新型的生物可降解聚氨基酯，其骨架中含有仲胺和叔胺，具有与聚乙烯亚胺（PEI）相当的转染效率和低细胞毒性。
Novel biodegradable poly( amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.