THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS.
THE CHRYSANTHEMUM PHENOTYPE OF IDIOPATHIC MULTIFOCAL CHOROIDITIS.
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DOI：
10.1097/iae.0000000000003815
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发表时间：
2023-08-01
影响因子：
3.3
通讯作者：
Tsui, Edmund
中科院分区：
文献类型：
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作者：
Ramtohul, Prithvi;Cicinelli, Maria Vittoria;Dolz-Marco, Rosa;Gal-Or, Orly;Mrejen, Sarah;Garcia-Martinez, Jesus R.;Goldberg, Alla;de Souza, Eduardo Cunha;Miserocchi, Elisabetta;Cunningham, Emmett T.;Yannuzzi, Lawrence A.;Freund, K. Bailey;Tsui, Edmund
关键词：
描述一种不同亚型的活动性特发性多灶性脉络膜炎(IMFC)病变的临床特征和多模式成像(MMI)特征，其中灰黄色脉络膜视网膜病变周围环绕较小的卫星斑点，这种表现称为“菊花性病变”。回顾性、观察性、多中心病例系列：眼部有活动性IMFC和菊花样病变。多模式成像的特点进行了回顾和介绍。20例25眼，女性12例，男性8例，年龄7~78岁，平均(35.8±17.0)岁。菊花病变均位于黄斑部(48.0%)或中/远周缘(52.0%)。每眼病变个数从1个(16.0%)到20个以上(56.0%)不等。在光学相干断层扫描(OCT)上，菊花病变具有典型的IMFC特征，包括视网膜下高反射物质裂开视网膜色素上皮/Bruchs膜(RPE/BRM)。菊花病变在眼底自发荧光成像上表现为弱自体荧光，在荧光素血管成像上表现为强荧光，在吲哚青绿血管成像上表现为弱荧光，在OCT血管成像上表现为脉络膜毛细血管血流信号缺陷。活动期IMFC可能表现为类似菊花样病变。在眼底镜检查中，独特的病变形态，大量的病变，以及独有的中远外周受累的高发生率，可能代表了IMFC的一个独特的表型。在这个25只眼的病例中，我们描述和分析了特发性多灶性脉络膜炎菊花表型的临床和多模式影像特征。
To describe the clinical characteristics and multimodal imaging (MMI) features of a distinctive subtype of active idiopathic multifocal choroiditis (iMFC) lesions with grey-yellow chorioretinal lesions surrounded by smaller satellite dots, a presentation referred to as “chrysanthemum lesions”. Retrospective, observational, multi-center case series of eyes with active iMFC and chrysanthemum lesions. Multimodal imaging features were reviewed and presented. Twenty-five eyes from 20 patients (12 women and 8 men), with a mean age of 35.8±17.0 years (range, 7 – 78 years) were included. Chrysanthemum lesions were equally located in the macula (48.0%) or the mid/far-periphery (52.0%). The number of lesions per eye varied from 1 (16.0%) to more than 20 (56.0%). On optical coherence tomography (OCT), chrysanthemum lesions showed typical features of iMFC, including subretinal hyperreflective material splitting the retinal pigment epithelium/Bruch’s membrane (RPE/BrM). Chrysanthemum lesions were hypoautofluorescent on fundus autofluorescence imaging, hyperfluorescent on fluorescein angiography, hypofluorescent on indocyanine green angiography, and associated with choriocapillaris flow signal deficit on OCT-angiography. Active iMFC may present with findings resembling chrysanthemum lesions. The distinctive lesion morphology on ophthalmoscopic examination, the high number of lesions, and the high prevalence of exclusive mid- and far-peripheral involvement may represent a distinctive phenotype of iMFC. In this case series of 25 eyes, we describe and analyze the clinical and multimodal imaging features of the chrysanthemum phenotype of idiopathic multifocal choroiditis.
影响因子：
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作者：
de Souza EC;de Campos VE;Duker JS
通讯作者：
Duker JS