Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer
Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer
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DOI：
10.1016/j.surg.2012.10.007
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发表时间：
2013-04-01
期刊：
影响因子：
3.8
通讯作者：
Birner, Peter
中科院分区：
文献类型：
--
作者：
Schoppmann, Sebastian F.;Jesch, Bettina;Birner, Peter
肿瘤相关淋巴网络是肿瘤细胞传播和转移的主要途径。在可能的淋巴管生成相关疗法的背景下，食管癌中淋巴管生成（通过淋巴微血管密度[LMVD]测量）和特异性淋巴血管侵袭（LVI）的临床影响尚不清楚。本研究的目的是评估淋巴管生成和LVI在食管癌大队列中的临床作用。为了对LMVD和LVI进行特异性评估，本研究从食管腺癌、鳞状细胞癌及其前体病变的前瞻性组织数据库中收集了393个组织样本。采用淋巴内皮选择性标志物podoplanin免疫染色法评估lvd和LVI。同时观察肿瘤周围炎性间质反应（ISR）。与肿瘤的组织学无关，高LAND患者发生LVI （P = 0.00123；回归系数[CR7 0.27]）和淋巴结转移（P = 0.00233）的风险显著增加。在52个月的随访中，高LMVD患者的总生存率明显降低(OS； P
Tumor-associated lymphatic networks are the primary routes for tumor cell dissemination and metastasis. Behind the background of possible lymphangiogenesis-associated therapies, the clinical impact of lymphangiogenesis (measured by lymphatic microvessel density [LMVD]) and specific lymphovascular invasion (LVI) in esophageal cancer remains unclear The aim of this study was to evaluate the clinical role of lymphangiogenesis and LVI in a large cohort of esophageal cancer.Methods. For the specific assessment of LMVD and LVI, 393 tissue samples from a prospective tissue databank of esophageal adenocarcinomas, squamous cell carcinomas, and their precursor lesions were included into this study. LMVD and LVI were assessed by immunostaining for podoplanin, a selective marker of lymphatic endothelium. In addition the peritumoral inflammatory stroma reaction (ISR) was assessed.Results. Patients with high LAND had a significant increased risk to develop LVI (P =.00123; coef ficient of regression [CR7 0.27) and lymph node metastasis (P =.00233), independent of the tumor's histology. During a follow-up of 52 months, patients with high LMVD had a significantly reduced overall survival (OS; P