Pd(en) as a Sequence-Selective Molecular Pinch for α-Helical Peptides

Pd(en) as a Sequence-Selective Molecular Pinch for α-Helical Peptides
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Pd(en) 作为 α-螺旋肽的序列选择性分子箍缩

DOI:
10.1246/cl.2001.16
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
S. Shinkai
S. Shinkai
中科院分区:
--
文献类型:
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作者:
I. Hamachi;Noriyuki Kasagi;Shigeki Kiyonaka;T. Nagase;Yasuko Mito;S. Shinkai

文献摘要

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发现钯(II)(乙二胺)配合物选择性地稳定了在i和i +(3或4)位置有两个组氨酸(His)残基的肽的α-螺旋构象,而在不同位置有一个或两个His的肽的螺旋构象则不稳定。
A palladium(II)(ethylenediamine) complex was found to selectively stabilize α-helix conformation of peptides having two histidine (His) residues at i and i + (3 or 4) positions, whereas the helix conformation of the other peptides having one or two His at different positions is destabilized.