THE PERIPHERAL NEUROPATHY OF VITAMIN-B12 DEFICIENCY
THE PERIPHERAL NEUROPATHY OF VITAMIN-B12 DEFICIENCY
复制标题
DOI：
10.1016/0022-510x(84)90147-3
复制
发表时间：
1984-01-01
影响因子：
4.4
通讯作者：
MCLEOD, JG
中科院分区：
文献类型：
--
作者：
MCCOMBE, PA;MCLEOD, JG
对 3 名维生素 B12 缺乏症和周围神经病变症状的患者进行了神经传导研究和腓肠神经活检。病理结果为轴突变性；没有脱髓鞘的证据。治疗开始后每隔 5-15 年对患者进行一次检查；通过治疗，神经病变的进展得到遏制，但在所有病例中，残留的神经异常仍然存在。一名患有自主神经病变的患者，经治疗后体位性低血压迅速完全缓解。
Nerve conduction studies and sural nerve biopsy were performed on 3 patients with vitamin B12 deficiency and symptoms of peripheral neuropathy. The pathological findings were those of axonal degeneration; there was no evidence of demyelination. The patients were reviewed at intervals of 5-15 yr commencement of treatment; progression of the neuropathy was arrested by treatment, but in all cases residual neurological abnormalities persisted. In 1 patient with autonomic neuropathy, the postural hypotension resolved rapidly and fully with treatment.