Body mass index, sex, and cardiovascular disease risk factors among Hispanic/Latino adults: Hispanic community health study/study of Latinos.
Body mass index, sex, and cardiovascular disease risk factors among Hispanic/Latino adults: Hispanic community health study/study of Latinos.
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DOI：
10.1161/jaha.114.000923
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发表时间：
2014-07-09
影响因子：
5.4
通讯作者：
Cai J
中科院分区：
文献类型：
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作者：
Kaplan RC;Avilés-Santa ML;Parrinello CM;Hanna DB;Jung M;Castañeda SF;Hankinson AL;Isasi CR;Birnbaum-Weitzman O;Kim RS;Daviglus ML;Talavera GA;Schneiderman N;Cai J
美国所有主要的西班牙裔/拉丁裔群体肥胖患病率都很高，且往往很严重。对于身体质量指数（BMI）极高的人群的心血管疾病（CVD）风险因素，人们知之甚少。
在美国西班牙裔男性（N = 6547）和女性（N = 9797）中，我们描述了包括高血压、血脂、糖尿病和C - 反应蛋白在内的心血管疾病风险因素在BMI和年龄范围内的梯度变化。在对年龄以及其他人口统计学和社会经济变量进行调整后，确定了每个BMI水平下心血管疾病风险因素患病率的性别差异。在患有II级或III级肥胖（BMI≥35 kg/m²，女性18%，男性12%）的人群中，在40岁左右，高血压、糖尿病、高密度脂蛋白胆固醇水平低以及C - 反应蛋白水平高的患病率接近或超过40%。虽然女性III级肥胖（BMI≥40 kg/m²）的患病率高于男性（分别为7%和4%），但在这个最高BMI类别中，男性患糖尿病、高血压和高血脂的相对患病率比女性高50%以上，而在其他BMI水平下，这些心血管疾病风险因素患病率的性别差异约为20%或更低。
BMI升高在西班牙裔/拉丁裔成年人中很常见，并且与大量心血管疾病风险因素相关。在最高BMI水平下，心血管疾病风险因素往往在成年后的最初几十年就出现，而且对男性的影响比女性更常见。
All major Hispanic/Latino groups in the United States have a high prevalence of obesity, which is often severe. Little is known about cardiovascular disease (CVD) risk factors among those at very high levels of body mass index (BMI). Among US Hispanic men (N=6547) and women (N=9797), we described gradients across the range of BMI and age in CVD risk factors including hypertension, serum lipids, diabetes, and C‐reactive protein. Sex differences in CVD risk factor prevalences were determined at each level of BMI, after adjustment for age and other demographic and socioeconomic variables. Among those with class II or III obesity (BMI ≥35 kg/m2, 18% women and 12% men), prevalences of hypertension, diabetes, low high‐density lipoprotein cholesterol level, and high C‐reactive protein level approached or exceeded 40% during the fourth decade of life. While women had a higher prevalence of class III obesity (BMI ≥40 kg/m2) than did men (7% and 4%, respectively), within this highest BMI category there was a >50% greater relative prevalence of diabetes, hypertension, and hyperlipidemia in men versus women, while sex differences in prevalence of these CVD risk factors were ≈20% or less at other BMI levels. Elevated BMI is common in Hispanic/Latino adults and is associated with a considerable excess of CVD risk factors. At the highest BMI levels, CVD risk factors often emerge in the earliest decades of adulthood and they affect men more often than women.