The temporal basis of angiogenesis.
The temporal basis of angiogenesis.
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DOI：
10.1098/rstb.2015.0522
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发表时间：
2017-05-19
期刊：
影响因子：
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通讯作者：
Chakravartula S
中科院分区：
文献类型：
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作者：
Bentley K;Chakravartula S
新血管生长（血管生成）的过程是高度动态的，涉及多种细胞类型的复杂协调。虽然这个过程必须随着时间的推移仔细展开，以产生功能性的，适应性良好的分支网络，但我们很少听说血管生成的时间属性，尽管时间是生物学其他领域的核心。在这里，我们提出了一种新的，基于时间的制定血管生成过程中的内皮细胞行为，并讨论了我们最近的一系列，集成在硅片/体内研究，在更广泛的文献背景下，这表明，组织条件可以局部适应集体细胞行为/决策的时间，以生长不同的血管网络架构。最近发现了越来越多的看似不相关的“时间调节因子”，包括组织衍生因子（例如，在癌症中发现的信号蛋白或高水平的VEGF）和细胞过程（例如，不对称细胞分裂或丝状伪足延伸），它们可以改变细胞决定迁移的速度。我们将认为，“时间适应”提供了一个新的帐户器官/疾病特异性血管形态，并揭示了“时间”作为一个新的治疗目标。因此，我们提出并解释了一个概念的转变，对血管生物学的“时间适应”的角度来看，事实上，生物学的其他领域的时间仍然难以捉摸。这篇文章是“系统形态动力学：了解组织硬件的发展”主题的一部分。
The process of new blood vessel growth (angiogenesis) is highly dynamic, involving complex coordination of multiple cell types. Though the process must carefully unfold over time to generate functional, well-adapted branching networks, we seldom hear about the time-based properties of angiogenesis, despite timing being central to other areas of biology. Here, we present a novel, time-based formulation of endothelial cell behaviour during angiogenesis and discuss a flurry of our recent, integrated in silico/in vivo studies, put in context to the wider literature, which demonstrate that tissue conditions can locally adapt the timing of collective cell behaviours/decisions to grow different vascular network architectures. A growing array of seemingly unrelated ‘temporal regulators’ have recently been uncovered, including tissue derived factors (e.g. semaphorins or the high levels of VEGF found in cancer) and cellular processes (e.g. asymmetric cell division or filopodia extension) that act to alter the speed of cellular decisions to migrate. We will argue that ‘temporal adaptation’ provides a novel account of organ/disease-specific vascular morphology and reveals ‘timing’ as a new target for therapeutics. We therefore propose and explain a conceptual shift towards a ‘temporal adaptation’ perspective in vascular biology, and indeed other areas of biology where timing remains elusive. This article is part of the themed issue ‘Systems morphodynamics: understanding the development of tissue hardware’.