Folate receptor overexpression is associated with poor outcome in breast cancer
Folate receptor overexpression is associated with poor outcome in breast cancer
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DOI：
10.1002/ijc.22811
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发表时间：
2007-09-01
影响因子：
6.4
通讯作者：
Low, Philip S.
中科院分区：
文献类型：
--
作者：
Hartmann, Lynn C.;Keeney, Gary L.;Low, Philip S.
高亲和力叶酸受体是一种膜相关糖蛋白，优先在上皮来源的癌症中表达，很少在正常细胞中表达。我们研究了它在乳腺癌中的表达模式，利用组织微阵列包含来自63例浸润性乳腺癌的样本，这些乳腺癌来自具有不同临床结果的女性。33名妇女组成了预后不良组，复发的中位时间为1.9年。30名妇女，良好的结果组，在诊断后至少7年没有复发。叶酸受体染色强度与预后密切相关。染色强度有两个汇总类别：弱（n = 42）或强（n = 21）。在强染色组中，21名妇女中有17名（81%）复发，中位生存期为2.4年。在弱染色组中，42名妇女中有16名（38%）复发。他们的中位生存期是无法估计的。校正肿瘤大小、淋巴结状态、ER状态、辅助治疗、组织学和肿瘤分级后，叶酸受体强染色仍与不良结局显著相关，p < 0.001。我们的工作需要在更大的队列中进行验证，但支持在乳腺癌管理中使用叶酸受体靶向方法的可能性。(C)2007 Wiley-Liss，Inc.
The high affinity folate receptor is a membrane-associated glycoprotein that is preferentially expressed in cancers of epithelial origin and rarely expressed in normal cells. We examined its expression pattern in breast cancer, utilizing a tissue microarray containing samples from 63 invasive breast cancers from women with divergent clinical outcomes. Thirty-three women comprised the poor outcome group with a median time to recurrence of 1.9 years. Thirty women, the good outcome group, were free of recurrence for a minimum of 7 years after diagnosis. The intensity of folate receptor staining was strongly correlated with outcome. There were two summary categories of staining intensity: weak (n = 42) or strong (n = 21). In the strong staining group, 17 of 21 women (81%) have recurred and their median survival is 2.4 years. In the weak staining group, 16 of 42 women (38%) have recurred. Their median survival is not estimable. After adjustment for tumor size, nodal status, ER status, adjuvant therapy, histology and tumor grade, strong staining for the folate receptor remained significantly associated with poor outcome, p < 0.001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer. (C) 2007 Wiley-Liss, Inc.