Effect of a 10-week Weight Loss Camp on Fatty Liver Disease and Insulin Sensitivity in Obese Danish Children
Effect of a 10-week Weight Loss Camp on Fatty Liver Disease and Insulin Sensitivity in Obese Danish Children
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DOI：
10.1097/mpg.0b013e31822cdedf
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发表时间：
2012-02-01
影响因子：
2.9
通讯作者：
Vilstrup, Hendrik
中科院分区：
文献类型：
--
作者：
Gronboek, Henning;Lange, Aksel;Vilstrup, Hendrik
背景与目的：儿童非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗和肥胖相关，是一个日益严重的问题，并增加了肝硬化、2型糖尿病和心血管并发症的风险。我们对肥胖儿童进行为期10周的“减肥营”住院治疗对NAFLD患病率和程度以及胰岛素敏感性的影响进行了为期12个月的随访。方法：117例肥胖白人儿童（体重指数28.0 +/- 3.6 kg/m(2)，年龄12.1 +/- 1.3岁），每天适度运动1小时，限制能量摄入，达到减肥目的。NAFLD的诊断和分级采用超声和转氨血。采用稳态模型评估和口服糖耐量试验评估胰岛素敏感性和糖耐量。我们进行了人体测量，并利用生物阻抗测定了身体成分。在117名儿童中，有71名儿童在进入营地时、在营地待了10周后和营地结束后12个月时收集了数据。结果：儿童在夏令营期间平均体重减轻7.1±2.7 kg。在基线时，43%的人有超声肝脂肪变性，50%的人转氨酶升高（50 - 25IU/L），胰岛素敏感性降低。这些异常相互关联，并在营地期间显著改善(P
Background and Objective: Childhood nonalcoholic fatty liver disease (NAFLD) associated with insulin resistance and obesity is a growing problem and increases the risk of cirrhosis, type 2 diabetes mellitus, and cardiovascular complications. We examined the effects of a 10-week "weight loss camp" residency in obese children on the prevalence and degree of NAFLD and insulin sensitivity with 12-month follow-up.Methods: At the camp, 117 obese white children (body mass index 28.0 +/- 3.6 kg/m(2), age 12.1 +/- 1.3 years) exercised moderately for 1 hour/day and restricted their energy intake to induce weight loss. NAFLD was diagnosed and graded using ultrasound and transaminasemia. Insulin sensitivity and glucose tolerance were assessed using homeostasis model assessment and oral glucose tolerance test. We performed anthropometric measurements and determined body composition using bioimpedance. Data were collected from 71 of 117 children at entry, after the 10 weeks at the camp, and 12 months after the camp ended.Results: The children showed an average weight loss of 7.1 +/- 2.7 kg during the camp. At baseline, 43% had ultrasonographic liver steatosis, 50% elevated transaminases (>25IU/L), and reduced insulin sensitivity. These abnormalities were mutually related and improved significantly during the camp (P