Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild-to-moderate psoriasis vulgaris: A multicenter randomized controlled trial.
Efficacy and safety of a topical moisturizer containing linoleic acid and ceramide for mild-to-moderate psoriasis vulgaris: A multicenter randomized controlled trial.
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含有亚油酸和神经酰胺的外用保湿霜治疗轻至中度寻常型银屑病的功效和安全性：一项多中心随机对照试验
DOI：
10.1111/dth.14263
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发表时间：
2020-11
影响因子：
3.6
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Li X;Yang Q;Zheng J;Gu H;Chen K;Jin H;He C;Xu AE;Xu J;Zhang J;Yu W;Guo Z;Xiong L;Song Y;Zhang L
银屑病是一种需要长期治疗的慢性复发性皮肤病。修复皮肤屏障功能的药物是银屑病局部治疗中非常宝贵的辅助药物。这项多中心、随机、对照试验评估了一种含亚油酸 - 神经酰胺的保湿剂（LA - Cer）对轻至中度寻常型银屑病的疗效和安全性。我们将来自中国北方和南方地区的178名患者随机分为两组：对照组的81名患者接受糠酸莫米松（MF，0.1%）乳膏治疗，而治疗组的86名患者接受MF联合LA - Cer治疗，为期4周。LA - Cer - MF组在局部使用糖皮质激素后继续使用保湿剂。主要终点指标，即银屑病面积和严重程度指数50（PASI 50）反应，显示LA - Cer - MF在第8周时复发率更低，具有优势。使用含LA - Cer的保湿剂作为维持治疗，在体表面积、PASI、研究者对皮肤干燥和脱屑的评估、医生对银屑病的整体评估评分以及患者生活质量方面，都使临床状况得到持续改善。因此，含LA - Cer的保湿剂是一种有前景的预防和治疗银屑病的药物，因为它增强了局部糖皮质激素诱导的治疗效果并延缓了复发。
Psoriasis is a chronic, recurrent skin disease requiring long‐term management. Agents that repair the skin's barrier function are invaluable additives in topical treatments of psoriasis. This multicenter, randomized, controlled trial evaluated the efficacy and safety of a linoleic acid‐ceramide‐containing moisturizer (LA‐Cer) for mild‐to‐moderate psoriasis vulgaris. We randomized 178 patients from both northern and southern regions of China into two groups: 81 patients in the control group received mometasone furoate (MF, 0.1%) cream, while MF in combination with LA‐Cer was administered to 86 patients in the treatment group for 4 weeks. The LA‐Cer‐MF group maintained the use of moisturizer after topical glucocorticoid administration. The primary endpoint, Psoriasis Area and Severity Index 50 (PASI 50) response, revealed the superiority of LA‐Cer‐MF with lower relapse rates at week 8. The use of the LA‐Cer‐containing moisturizer as maintenance therapy resulted in a continuous improvement in the clinical state in terms of body surface area, PASI, investigators' assessment of skin dryness and desquamation, and Physician Global Assessment of Psoriasis score, and in the patients' quality of life. Thus, the LA‐Cer‐containing moisturizer is a promising agent to prevent and treat psoriasis as it enhances the therapeutic effect induced by topical glucocorticoids and delays relapse.
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影响因子：
6.5
作者：
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通讯作者：
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