Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain
Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain
复制标题
电休克对大鼠脑单胺能受体结合位点的影响
作者：
D. A. Bergstrom;K. Kellar
长期服用三环类抗抑郁药物或单胺氧化酶抑制剂对治疗内源性抑郁是有效的，已被证明降低了去甲肾上腺素(NA)刺激的腺苷酸环1-5的敏感性，并降低了大鼠脑内β-肾上腺素能受体结合部位的表观密度。抗抑郁药物对受体机制的这种改变似乎是选择性的，因为三环类药物Desire-mine7不改变大鼠皮质中α-肾上腺素能和5-羟色胺能受体的结合。因此，人们很有兴趣知道其他形式的抗抑郁药物干预是否会改变大脑中的受体机制，如果是的话，它们是否表现出与抗抑郁药物类似的时间进程和选择性。在这里，我们研究了单次和多次电休克对大鼠脑内单胺能受体结合部位的影响，并报告了β能受体密度降低。
CHRONIC administration of either tricyclic antidepressant drugs or monoamine oxidase inhibitors, which are effective in the treatment of endogenous depression, has been shown to decrease the sensitivity of nor adrenaline (NA)-stimulated adenylate cyclase1–5 and to decrease the apparent density of β-adrenergic receptor binding sites in rat brain6–10. This alteration in receptor mechanisms by antidepressant drugs seems to be selective, as neither α-adrenergic nor serotonergic receptor binding in rat cortex is altered by the tricyclic drug desipramine7. It is therefore of interest to know whether other forms of antidepressant intervention alter receptor mechanisms in the brain and if so, whether they display a time course and selectivity similar to that of antidepressant drugs. Here, we have investigated the effects of a single and of multiple electroconvulsive shocks (ECS) on rat brain monoaminergic receptor binding sites and report that the density of β-adrenergic receptors is decreased.
新生儿 6-羟基多巴胺治疗后脑部 β-肾上腺素能受体的发育。
影响因子：
3.8
作者：
Lorton,D;Bartolome,J;Slotkin,TA;Davis,JN
通讯作者：
Davis,JN