Neuropsychological profiles of manganese neurotoxicity
Neuropsychological profiles of manganese neurotoxicity
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DOI：
10.1111/j.1468-1331.2006.01407.x
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发表时间：
2006-10-01
影响因子：
5.1
通讯作者：
Josephs, K. A.
中科院分区：
文献类型：
--
作者：
Klos, K. J.;Chandler, M.;Josephs, K. A.
锰神经毒性的病因是异质性的，包括暴露于焊接烟雾、慢性肝功能衰竭和慢性全胃肠外营养（TPN）。我们最近报道，认知功能障碍发生在焊工和慢性肝功能衰竭的患者，他们有锰神经毒性的证据，包括异常的磁共振成像（MRI）基底节T1高信号。在这项研究中，我们比较了三种不同病因的锰神经毒性和基底节T1高信号患者的神经心理学特征：焊接，慢性肝功能衰竭和慢性TPN。在所有三组中，神经心理学特征表明额叶和皮质下认知障碍，非焊接组中发生更广泛的异常。
The etiology of manganese neurotoxicity is heterogenous and includes exposure to welding fumes, chronic liver failure, and chronic total parental nutrition (TPN). We recently reported that cognitive impairment occurs in welders and patients with chronic liver failure who had evidence of manganese neurotoxicity including abnormal magnetic resonance imaging (MRI) basal ganglia T1 hyperintensity. In this study, we compared the neuropsychological profiles of patients with manganese neurotoxicity and basal ganglia T1 hyperintensities from three different etiologies: welding, chronic liver failure, and chronic TPN. Across all three groups, the neuropsychological profiles suggest frontal and subcortical cognitive impairment, with more widespread abnormalities occurring in the non-welding groups.